The California Institute for Regenerative Medicine (CIRM) is a major funding agency for stem cell research in the Golden State. Since voters approved the establishment of the agency in 2004, the CIRM has spent billions on research and facilities with the aim of making California the stem cell capital of the US. Now, in a move to advance that research mission even further, the agency has announced awards of $32M to investigators and stem cell companies to create a biobank of diseased cell lines for the use of researchers around the world. Called the Human Induced Pluripotent Stem Cell (hiPSC) Initiative Awards, the project will generate and ensure the availability of high quality disease-specific hiPSC resources for disease modeling, target discovery and drug discovery and development for prevalent, genetically complex diseases.
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The tighter funding gets, the more likely it is that young investigators pursuing big ideas will get passed over and science grant money will stay with safer, more established projects. Fortunately there are exceptions to that general rule, including a new program established by the Paul G. Allen Family Foundation specifically to support select pioneering research projects that aim to unlock fundamental questions in biology. They recently awarded investigators from 5 prestigious US universities a total of $7.5M to pursue basic questions about the origins and mechanisms of cellular behavior. One of those 5 Distinguished Investigator awards, for $1.6M, is going to quantitative biologist and recent hire Suckjoon Jun, who works in physics and molecular biology at the University of California San Diego. His project title is "Cell-size control and its evolution at the single-cell level," and includes developing methods to perform long-term directed single-cell evolution experiments, as well as single-cell on-chip manipulation, sequencing, and mathematical modeling.
Tags: 2014, CA, University of California San Diego, 2013, cell biology, Southwest, California, University of California, Cell Research, San Diego, SDVS, Funding, UCSD, Biotechnology Vendor Showcase
Since its first lemonade stand was set up in 2000 by a little girl with cancer, the Alex's Lemonade Stand Foundation (ALSF) has raised over $60M to support pediatric cancer research at institutions across the United States. That's a lot of lemonade. While lemonade stands are still a staple of the organization's activities, celebrity support and large fund raising events like the recent "Lemon Ball" (which raised a record $825K) allow ALSF to leverage the kind of funds that really make a difference. In a recent round of funding awards, the University of California San Francisco's Benioff Children's Hospital was named a Center of Excellence by the foundation and given $1.75M to speed translational research programs and training over the next five years. Chief investigator on the grant is Dr. Katherine Matthay, chief of pediatric oncology at Benioff. She says of the ALSF award in a recent news release:
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The Brain Activity Map project could be the next big federal life science research endeavor, with no less a goal than the mapping of the entire living brain and all its neuronal activity. Like the Human Genome Project of the 90's, the not insignificant financial outlay is being presented as an investment that will net even bigger returns, both in terms of new technology and a vastly increased understanding of the mind. President Obama is expected to include the multi-billion dollar, decade-long funding in his upcoming budget proposal, and neuroscience research was a topic he addressed specifically in his recent State of the Union address.
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The National Eye Institute, an NIH agency dedicated to vision research, recently announced the winners of their Challenge to Identify Audacious Goals in Vision Research and Blindness Rehabilitation, or the Audacious Goals Challenge for short. The competition was open to professionals and members of the public and called upon them to think big and bold about vision research goals for the next decades. The prize money was nominal ($3,000) but included an invitation and travel money to attend and present their ideas at the NEI Audacious Goals Development Meeting in Maryland later this month. The real prize, of course, was the opportunity to help set research and funding goals for the next 10-12 years. Of the 500 or so proposals submitted, 10 visionaries were selected as winners.
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Plant pathogens like the one that led to the notorious Irish Potato Famine of the 1840's are still the subject of intense research at institutions like the University of California Riverside, as the battle continues between mega-crop farmers and diseases that have learned to infiltrate the plant’s immune system. Just what the genetic mechanism is that allows for that infiltration has remained elusive until recently. Studying the notorious oomycete pathogen Phytophthora in its multiple forms, UC Riverside researchers have identified a crucial step in the disease attack of the cell, namely the activity of virulence proteins in blocking RNA silencing pathways, which leads to immune system compromise. The role of RNA silencing as an important immune component is a new research direction and one that is being pioneered at UCR.
Tags: 2014, CA, 2013, University of California Riverside, genome research, Southwest, California, University of California, Plant science, BioResearch Product Faire Event, Funding, Riverside, NSF, Southwest Region, UCR
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You might expect the barrage of brilliant lab-on-a-cell-phone inventions that come out of the Ozcan Nano/Bio Photonics Lab at the University of California Los Angeles to eventually dwindle, or perhaps only leave us moderately impressed after a while, but that's not the case. Less than three weeks into 2013, the Ozcan Research Group published on their development of a new optical microscopy platform which uses liquid nanolenses that self-assemble around tiny objects (in the sub–100-nanometer range), allowing it to detect viruses and nanoparticles. That paper was published online in the journal Nature Photonics and was the subject of a recent UCLA research news release. Also this month, the Royal Society of Chemistry published the paper Cost-effective and Rapid Blood Analysis on a Cell-phone. And the international society for optics and photonics, SPIE, announced a new annual award for 2013: the Biophotonics Technology Innovator Award. One guess who its first recipient is? Not a shabby way to start the new year at all.
Tags: 2014, CA, University of California Los Angeles, 2013, Photonics, Ozcan Nano/Bio Photonics Lab, Microscopy, Lab-on-a-chip Technology, Southwest, California, University of California, Los Angeles, LAVS, UCLA, Biotechnology Vendor Showcase
Dr. Gary Michelson is a retired Los Angeles surgeon who made a lot of money ($1.35B) from a spinal surgical invention in 2005. Since then he's devoted himself and his considerable resources to philanthropy. One of his most passionate causes is reducing the rate of euthanasia for unwanted pets by promoting spaying and neutering, along with shelter adoption, training, and good vet care through the Los Angeles group Found Animals. Not content with the usual invasive practice of sterilizing pets, he also created the Michelson Prize and Grants to challenge research scientists to come up with a cheap, safe, and effective one-dose pill for cats and dogs to induce permanent infertility. The winner of the Michelson Prize in Reproductive Biology will take home $25M and the satisfaction of knowing that fewer pets will be put down because of overpopulation.
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2012 was a big year for the science of snipping DNA to introduce genetic changes into a cell, also known as genome editing. Though Science magazine hailed two new techniques for selectively cutting and pasting DNA in the field of genome engineering as together constituting one of the Top 10 scientific breakthroughs of the year, those methods may already have been surpassed by researchers at the University of California Berkeley using RNA and a single protein. Faster, simpler, and cheaper, the UCB team led by Dr. Jennifer Doudna published initial results of their work genetically modifying bacteria using the RNA-based DNA cleavage technique last summer. The response from the the life science community was extremely positive, with reviews calling it a "tour de force" and a "a real hit," according to the latest press release. Now three more papers are coming out based on the work of the Doudna Lab showing that the RNA programming technique using a bacterial enzyme known as Cas9 is equally effective in making alterations to human genes.
Tags: 2014, CA, 2013, University of California Berkeley, AIDS Research, Molecular Engineering, gene therapy, Southwest, California, University of California, genetic engineering, Berkeley, BioResearch Product Faire Event, Harvard, genomics research, UC Berkeley, UCBerk