Most people think of paralysis in terms of not being able to move or walk. But there is another side to being paralyzed , the lack of sensation. The inability to feel pain leaves the person susceptible to burns from inadvertent contact with hot surfaces. Researchers at the Broad Center for Regenerative Medicine and Stem Cell Research at UCLA have developed a new protocol which could serve as the first step toward stem cell-based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body.
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In June, the Texas legislature unanimously passed Charlie’s Law which allows patients with chronic and terminal diseases access to experimental stem cell interventions. The law, named after the late Texas State representative Charlie Howard, is the first of its kind in the U.S.
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UC Davis has a long history of ground breaking stem cell research. Possible therapies studied range from advanced wound healing, treating HIV, and reduced vision loss to the regeneration of bone in otherwise non-healing fractures. Now The California Institute for Regenerative Medicine (CIRM) has awarded UC Davis Medical Center scientists nearly $8 million in research funding to launch a special clinical trials program in Sacramento. The goal of the grant is to accelerate the development and delivery of stem cell therapies in human patients.
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Researchers at UCLA believe using the patient’s own cells to create stem cells for therapeutic purposes is the future of medicine. A recently published study by scientists at UCLA demonstrates how specialized proteins change the cellular characteristics of skin cells to create induced pluripotent stem cells. These stem cells have the ability to turn into any cell type within the body. Also at UCLA, a clinical trial which uses the baby’s own blood-forming stem cells to treat the immune deficiency condition ADA-SCID, better known as “bubble baby disease,” was recently awarded a $20M grant from the California Institute for Regenerative Medicine.
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Dr. Madelaine Bartlett, a biologist at the University of Massachusetts in Amherst, recently received a four-year $4 million grant from the National Science Foundation. The new research funding will allow Barlett and colleagues from UMass and other institutions to study the genes that regulate plant stem cell biology and their effect on fruit size and yield.
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Researchers at the University of Colorado, Boulder have recently discovered information about stem cell division that may change the way we approach regenerative medicine and cancer research. These findings were published as the cover story in Science for its February 5th issue.
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(Original article from 2012 by Jaimee Saliba. Updated information added by Katey Rein.)
The University of Pittsburgh has strong ties with the Pittsburgh Veteran's Administration Medical Center located next door, and in the past few years those relations have been strengthened with the establishment of the UP School of Medicine Center for Military Medicine Research as well as a new research facility at the VA's University Drive campus.
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An estimated 30,000 people in the United States are afflicted with Huntington’s disease. Receiving a diagnosis of this genetic neurodegenerative disorder is unimaginably devastating. Sufferers slowly lose control of their movement and develop psychiatric problems over the course of 10-25 years, and often the disease is undetected until adulthood. Just this year, UC Davis researchers in Sacramento, California have discovered that human mesenchymal stem cells (MSCs) - cells with the ability to differentiate into bone cells, muscle cells, and other cell types - could be the key to developing an effective new therapy to treat Huntington’s. The promising findings are published in the journal Molecular Therapy.
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Millions of people suffer from allergies nationwide, (up to 30% of Americans, according to the Center for Disease Control), but for most, a healthy immune system and a course of antihistamines is all that is needed for a little relief.
For others, however, diseases that complicate and degrade the immune system make every microbe and bacteria a potentially fatal nightmare. In recent years, people suffering from immune deficiencies have found some home in stem-cell transplants and other therapies, but their hope is tempered by inherent toxicities and associated side effects.
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Hypothalamic neurons orchestrate many essential physiological and behavioral processes via secreted neuropeptides, and are relevant to human diseases such as obesity, narcolepsy and infertility. A recent collaboration of scientists from New York, Toronto, and Tokyo, and Harvard Stem Cell Institute (HSCI) researchers have devised two methods for using stem cells to generate the type of neurons that help regulate behavioral and basic physiological functions in the human body, such as obesity and hypertension, as well as sleep, mood, and some social disorders.
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