The tighter funding gets, the more likely it is that young investigators pursuing big ideas will get passed over and science grant money will stay with safer, more established projects. Fortunately there are exceptions to that general rule, including a new program established by the Paul G. Allen Family Foundation specifically to support select pioneering research projects that aim to unlock fundamental questions in biology. They recently awarded investigators from 5 prestigious US universities a total of $7.5M to pursue basic questions about the origins and mechanisms of cellular behavior. One of those 5 Distinguished Investigator awards, for $1.6M, is going to quantitative biologist and recent hire Suckjoon Jun, who works in physics and molecular biology at the University of California San Diego. His project title is "Cell-size control and its evolution at the single-cell level," and includes developing methods to perform long-term directed single-cell evolution experiments, as well as single-cell on-chip manipulation, sequencing, and mathematical modeling.
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Tags: 2014, CA, University of California San Diego, 2013, cell biology, Southwest, California, University of California, Cell Research, San Diego, SDVS, Funding, UCSD, Biotechnology Vendor Showcase
Lab scientists at the University of Pittsburgh Cancer Institute and UP's Center for Biologic Imaging have recently published an important paper in the Journal of Cell Science that sheds light on a novel method of interrupting mitosis in a cell by effectively depriving its mitochondria of a key protein. The resulting replication stress means cancer cells are stopped from successfully multiplying. Colorful images of the targeted cells actually show them stuck in anaphase trying to divide and subsequently tearing themselves apart. By identifying a compound that carries out this protein interference and disrupts normal mitochondrial fission, researchers have identified a promising therapeutic avenue for halting cancer growth.
Tags: 2014, 2013, University of Pittsburgh, Pennsylvania, Northeast, Hillman Cancer Center, cancer research, cell biology, Microscopy, UPITT, Cell Research, BioResearch Product Faire Event, PA, NIH, Pittsburgh, Northeast Region
Since its first lemonade stand was set up in 2000 by a little girl with cancer, the Alex's Lemonade Stand Foundation (ALSF) has raised over $60M to support pediatric cancer research at institutions across the United States. That's a lot of lemonade. While lemonade stands are still a staple of the organization's activities, celebrity support and large fund raising events like the recent "Lemon Ball" (which raised a record $825K) allow ALSF to leverage the kind of funds that really make a difference. In a recent round of funding awards, the University of California San Francisco's Benioff Children's Hospital was named a Center of Excellence by the foundation and given $1.75M to speed translational research programs and training over the next five years. Chief investigator on the grant is Dr. Katherine Matthay, chief of pediatric oncology at Benioff. She says of the ALSF award in a recent news release:
Tags: 2014, CA, University of California San Francisco, 2013, University of California San Francisco Mission Bay, University of California San Francisco Parnassus, cancer research, Southwest, California, University of California, Pediatric Cancer Research, San Francisco, SFVS, BioResearch Product Faire Event, Funding, San Francisco cancer research, Biotechnology Vendor Showcase, UCSF, Parnassus, Mission Bay, Benioff Children's Hospital
Of the eleven scientists just announced as winners of the new Life Sciences Breakthrough Prize, four of them have their labs within a block or two of each other in Manhattan: two at Rockefeller University, one at Weill Cornell Medical College, and one at Memorial Sloan-Kettering Cancer Center. The prize, given to recognize past achievement in research aimed at curing disease and extending human life, comes with $3M to allow each of those researchers the freedom and flexibility to pursue even more groundbreaking work in the future. The founding sponsors of the prize are tech entrepreneurs Sergey Brin (Google) and Anne Wojcicki, Mark Zuckerberg (Facebook) and Priscilla Chan, Art Levinson (Apple), and Yuri Milner (venture capitalist). The 11 winners this year will serve on the board to choose 5 winners each in subsequent years.
Tags: 2014, Rockefeller University, 2013, Northeast, cancer research, women in science, New York, Weill Cornell, Memorial Sloan-Kettering Cancer Center, RockU, BioResearch Product Faire Event, NY, New York City, Cancer Center, Rockefeller
The Brain Activity Map project could be the next big federal life science research endeavor, with no less a goal than the mapping of the entire living brain and all its neuronal activity. Like the Human Genome Project of the 90's, the not insignificant financial outlay is being presented as an investment that will net even bigger returns, both in terms of new technology and a vastly increased understanding of the mind. President Obama is expected to include the multi-billion dollar, decade-long funding in his upcoming budget proposal, and neuroscience research was a topic he addressed specifically in his recent State of the Union address.
Tags: 2014, CA, University of California San Diego, 2013, Northeast, University of California Berkeley, New York, Columbia University, Southwest, California, University of California, Berkeley, Neuroscience, San Diego, SDVS, Columbia, BioResearch Product Faire Event, Funding, UCSD, NY, NIH, Columbia University Medical Center, Biotechnology Vendor Showcase, Berkeley Labs, UCBerk
The National Eye Institute, an NIH agency dedicated to vision research, recently announced the winners of their Challenge to Identify Audacious Goals in Vision Research and Blindness Rehabilitation, or the Audacious Goals Challenge for short. The competition was open to professionals and members of the public and called upon them to think big and bold about vision research goals for the next decades. The prize money was nominal ($3,000) but included an invitation and travel money to attend and present their ideas at the NEI Audacious Goals Development Meeting in Maryland later this month. The real prize, of course, was the opportunity to help set research and funding goals for the next 10-12 years. Of the 500 or so proposals submitted, 10 visionaries were selected as winners.
Tags: University of Michigan, 2014, CA, Harvard University, Midwest, 2013, Northeast, university of utah, Washington University, Missouri, WashU, UUtah, St. Louis Bioresearch Product Faire Event, Oregon Health and Science University, Northwest, crowdsourcing, Vision Sciences Research, National Eye Institute (NEI), Blindness Rehabilitation, Southwest, University of Alabama, Southern, UT, Ann Arbor, Boston, BioResearch Product Faire Event, Funding, MI, MA, NIH, Harvard, OR, Salt Lake City, Birmingham, AL, UCSB, Santa Barbara, OHSU, Portland, UMich, UC Santa Barbara, Rehabilitation
Plant pathogens like the one that led to the notorious Irish Potato Famine of the 1840's are still the subject of intense research at institutions like the University of California Riverside, as the battle continues between mega-crop farmers and diseases that have learned to infiltrate the plant’s immune system. Just what the genetic mechanism is that allows for that infiltration has remained elusive until recently. Studying the notorious oomycete pathogen Phytophthora in its multiple forms, UC Riverside researchers have identified a crucial step in the disease attack of the cell, namely the activity of virulence proteins in blocking RNA silencing pathways, which leads to immune system compromise. The role of RNA silencing as an important immune component is a new research direction and one that is being pioneered at UCR.
Tags: 2014, CA, 2013, University of California Riverside, genome research, Southwest, California, University of California, Plant science, BioResearch Product Faire Event, Funding, Riverside, NSF, Southwest Region, UCR
Long considered one of the inferior senses, anyone who has lost their ability to taste as a result of age or cancer treatment will tell you life's luster is considerably dimmed in the absence of this sensory experience. Fortunately, research into taste and smell is going strong in Philadelphia at the Monell Chemical Senses Center, which is the only non-profit scientific basic research institute in the world dedicated entirely to understanding these intertwined senses. Once an entity within the University of Pennsylvania, the Center branched out on its own several decades ago, with labs a few blocks from the Penn campus on Market Street. Researchers at Monell work interdisciplinarily and many have joint appointments with Penn. Other research projects are carried out in conjunction with scientists at Thomas Jefferson University, also in Philly, and indeed with university and private lab investigators around the world.
Tags: 2014, 2013, Pennsylvania, Northeast, University of Pennsylvania, UPenn, Thomas Jefferson University, Stem cell research, taste buds, Monell Chemical Senses Center, Philadelphia, BioResearch Product Faire Event, PA, ThomJeff, taste
Tags: 2014, CA, University of California San Diego, 2013, Southwest, California, University of California, Autism, Neuroscience, San Diego, SDVS, UCSD, UC San Diego, Research, La Jolla, Biotechnology Vendor Showcase, Southwest Region
The Knight Cancer Institute at Oregon Health & Science University (OHSU) in Portland has just announced an important partnership with San Diego-based bioprinting technology company Organovo. Research into the biology of cancer, especially how it metastasizes, has been complicated in the past by the limitations of animal models and cell cultures, which really don't tell us enough about the workings of cancer within a human being. Organovo creates living, 3-D human tissue using their bioprinting device, the NovoGen MMX (below). The partnership between OHSU and Organovo will allow cancer research at Knight Institute labs to much more closely model the complex architecture of malignancy within the human body, using in vitro tissue. Ultimately this will lead to the development of more accurate therapeutics and pre-clinical trials.
Tags: 2014, 2013, Oregon Health Sciences University, Oregon Health and Science University, Northwest, cancer research, Oregon, Cancer Treatment, bioprinting, BioResearch Product Faire Event, Funding, Front Line event, OR, OHSU, Portland, Northwest Region