Two prominent researchers at UC Davis are under a microscope for their work in stem-cell biotechnology. The pair from University of California, Davis was awarded close to $4 million in funding to improve biotechnology intended for physicians studying stem cell treatments.
The two grant awards, of over $1.8 million each, were awarded to Laura Marcu and Kent Leach by the California Institute for Regenerative Medicine (CIRM) to continue developing technology that is used in stem cell treatments for vascular disease, bone and cartilage repair.
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Young scientists often contribute in spectacular ways to bioresearch. Without adequate funding, however, many important and dedicated junior scientists are limited in how they are able to contribute to scientific understanding.
Paying for lab equipment, salaries, and adequate research resources can all be limiting factors for some scientists, but perhaps not for junior post doctoral fellows working on stem cell research at the University of Southern California.
Thanks to a recent gift from the Hearst Foundations to USC in the amount of $300,000, exceptional junior postdoctoral fellows can continue to pursue stem cell research and work on important projects at USC.
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A research team at the UC San Diego’s Moores Cancer Center recently received a major new grant from the California Institute for Regenerative Medicine (CIRM) for a groundbreaking cancer study. The research will be led by Thomas J. Kipps, MD, PhD, deputy director of research operations at the Moores Cancer Center and a professor of medicine at UC San Diego (Image courtesy of UCSD).
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Two UCLA Researchers recently received major multimillion dollar stem cell grants to help bring the benefits of new stem cell research to patients. These grants will fund two groundbreaking clinical trials set to begin in the beginning of 2014.
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Researchers at Harvard University have recently published the results of a human clinical trial of a therapeutic that could increase the chances of success for blood stem cell transplantation. This will be the first time that the Harvard Stem Cell Institute has brought a discovery from the lab through clinical trials, marking the success of Harvard’s nine year-old goal of conducting groundbreaking research through the institute.
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Researchers at Emory University have discovered a way of packaging stem cells that make them much more effective in heart therapies. Using a capsule made of alginate, a gel-like substance, the researchers package the stem cells and attach them to the heart within a patch. According to Emory University, this capsule cause the stem cells’ healing to take place over time, rather than dying soon after they are introduced to the body, as they do without the capsule.
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Funded in part by grants from the California Institute for Regenerative Medicine and the NIH, researchers at the University of California, San Diego have come up with a simple, easily repeated RNA-based technique of generating human induced pluripotent stem cells (iPSCs). The study was published in the August 1st edition of Cell Stem Cell. The researchers’ method has wide-ranging applications for others searching for new cell therapies and use in other stem cell studies.
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As humans, our bodies have the ability to naturally regenerate both skin and hair, but we only get two sets of teeth, and that's one set more than many other mammals. Reptiles and fish, on the other hand, have the ability to regrow teeth throughout their lifetime. Though we have guessed that specialized stem cells are involved, the cellular and molecular mechanisms behind tooth renewal in these animals have not been well understood until now. A research team at the University of Southern California's Keck School of Medicine, led by Dr. Cheng-Ming Chuong, has recently published an article in PNAS detailing their study into the regrowth of alligator teeth. They chose a crocodilian model because the dentition is well-organized and implanted in sockets of the dental bone, similar to that of mammals (if more extensive) yet with the capacity for renewal. Contributors to the research included colleagues in Georgia, China, and the Louisiana Department of Wildlife and Fisheries, who presumably provided the live research subjects.
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The California Institute for Regenerative Medicine (CIRM) is a major funding agency for stem cell research in the Golden State. Since voters approved the establishment of the agency in 2004, the CIRM has spent billions on research and facilities with the aim of making California the stem cell capital of the US. Now, in a move to advance that research mission even further, the agency has announced awards of $32M to investigators and stem cell companies to create a biobank of diseased cell lines for the use of researchers around the world. Called the Human Induced Pluripotent Stem Cell (hiPSC) Initiative Awards, the project will generate and ensure the availability of high quality disease-specific hiPSC resources for disease modeling, target discovery and drug discovery and development for prevalent, genetically complex diseases.
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