Researchers at the University of Minnesota, Twin Cities have created a new lab-grown blood vessel replacement that is composed completely of biological materials, yet contains no living cells at implantation. It is the first-of-its-kind nonsynthetic, decellularized graft that becomes repopulated with the recipient’s own cells after implanted. This discovery could help tens of thousands of kidney dialysis patients each year. It could also be adapted for use as coronary and peripheral bypass blood vessels and tubular heart valves in the future.
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Rockefeller University received a $25 million gift from the Robertson Foundation that will be used to create the Robertson Therapeutic Development Fund. This fund will be used to help turn basic research discoveries into new medical therapies by providing support for dozens of Rockefeller projects over the next five years. Research grants ranging from $10,000 to $1 million will be awarded from the fund in order to provide Rockefeller scientists with the resources they need to take exceptionally promising research initiatives through the steps that lead to breakthrough medications, new diagnostic tests or other clinical innovations.
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Mechthild Tegeder, a professor of Plant Molecular Physiology at Washington State University, has designed a way to dramatically increase the yield and quality of soybeans. Tegeder accomplished this by developing a novel way to double the amount of nitrogen fixed by the plants. The agricultural research study indicates a breakthrough that could help meet society's need to feed an increasing population while also protecting the environment.
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Researchers at Emory University and Children’s Healthcare of Atlanta will soon be testing a vaccine that could protect patients against a strain of bird flu, H7N9 influenza, which caused a illness and death in China last spring. The clinical trial will be sponsored by the National Institute of Allergy and Infectious Diseases of the NIH.
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Researchers at Duke University recently made a groundbreaking contribution to the life sciences research field: The Duke researchers found that using certain bone grafting material for spinal fusion only sometimes increases the risk for benign tumors, and it does not increase the risk for cancer. Benign tumors were more common in patients who received the bone promoter recombinant human bone morphogenetic protein 2, also known as BMP.
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Researchers at the University of Pittsburgh have made a groundbreaking contribution to life science research: Researchers helped a mouse heart to beat again after its own cells were replaced with human heart precursor cells, marking the first time this has ever been done. According to a University of Pittsburgh news article, the researchers say it may soon be possible to take a skin biopsy from a human patient to regenerate an organ able to be transplanted.
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Researchers at the University of Pittsburgh have developed a way to mimic the biological responses of animals such as octopi or cuttlefish, which change their shape in the face of danger, by eliciting a biomimetic response using hydrogels. Hydrogels are used in most contact lenses and microfluidic or fluid-controlled technologies already, but the University of Pittsburgh researchers were able to redesign them to be reconfigured and controlled by light in a self-sustained movement. The study was recently published in the journal Advanced Functional Materials.
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A new study at the University of Pennsylvania, published in the journal PLOS ONE, has had researchers develop a variant of the mu opioid receptor that is water-soluble and can be grown in large quantities in bacteria. When the mu opiod receptor binds with opioid molecules, a strong reduction in the sensation of pain occurs. Unfortunately, fatal side effects can occur. According to a University of Pennsylvania news article, researchers at the university sought to address this issue by identifying the hydrophobic amino acids on the exterior of a structured model of the protein.
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Researchers at Stony Brook University in collaboration with colleagues at Johns Hopkins School of Medicine used DNA sequencing methods to make a new discovery: the direct causation of exposure to aristolochic acid (AA), which is found in a plant that’s been used in herbal remedies for thousands of years, in the development of urothelial cancer.
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