Six teams of researchers from leading univerisites are going to receive a set of three-year grants, totaling over $7.5 million, to create lab-grown brain cells in a process called neuronal maturation.
The funding to the various universities was made possible by The Paul G. Allen Family Foundation as part of its Allen Distinguished Investigator grants, and will ensure the continued development of important neuroscience research.
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Over the past 15 years, the Neuroscience Institute at the University of Cincinnati has grown immensely. Starting out with only a few researchers and physicians, the center has continuously grown in amount of faculty members, and funding received. Since its founding, more than $60 million has been donated to the institute, helping it become the leading neuroscience research and care center in the Cincinnati area.
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The Mount Sinai Health System in New York, composed of a medical school and seven hospitals throughout New York City, is a leading institution in life science research. Scientists here frequently produce leading research results and publish beneficial papers to the life sciences. Within the medical school and the hospitals, there are dozens of research centers and institutes that perform this world-class research.
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There are many well-known neurodegenerative diseases like Alzheimer's and Parkinson's that are caused by the loss of neurons which can lead to memory loss or the loss of nerve function. Neurodegenerative diseases can also occur from other diseases, such as HIV which can induce dementia. Researchers at Georgetown University in Washington D.C. have been studying different molecular mechanisms that contribute to Alzheimer's disease and HIV-induced dementia.
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The Fred Hutchinson Cancer Research Center and the University of Washington Medicine in Seattle are pleased to announce the arrival soon of Dr. Eric Holland, a world-class brain cancer research scientist and neurosurgeon, who will head up the Human Biology Division at Hutch as well as the Alvord Brain Tumor Center at UW. The eminent MD/PhD is being lured away from Manhattan's Memorial Sloan-Kettering Cancer Center, where he directs the MSKCC brain tumor center and has his lab within the Cancer Biology and Genetics Program, where his team studies the molecular mechanisms underlying the development of central nervous system tumors. In addition to being the recipient of many prestigious awards over years, Holland brings with him over $3M a year in NIH/NCI funding. It's unclear how many of his 13 lab members will follow him across the country to take on new challenges at Hutch and UW.
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Dr. Thomas Jessell is a developmental neurobiologist at Columbia University Medical Center and the latest recipient of the Scolnick Prize in Neuroscience, which includes a $100,000 award. In the Jessell Lab in the Hammer Health Sciences Building, researchers study the vertebrate central nervous system to understand how neurons become encoded at the embryonic level, particularly in the spinal cord. The Scolnick Prize singles out Jessell's work for identifying signaling molecules and transcriptional code that establish a linkage between functional circuitry and motor behavior. Also a member of Columbia's Motor Neuron Center, which is dedicated to the study of motor neuron diseases like ALS, Dr. Jessell is a faculty member in the Department of Biochemistry and Molecular Biophysics, a Howard Hughes Medical Institute investigator, and part of the larger Columbia Neuroscience interdisciplinary research community. He will travel to Boston in April to accept the prize and deliver a lecture (see image at right). The Scolnick Prize is given out by the McGovern Institute for Brain Research at MIT. According to McGovern chairman Robert Desimone, from a recent CUMC press release:
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The Brain Activity Map project could be the next big federal life science research endeavor, with no less a goal than the mapping of the entire living brain and all its neuronal activity. Like the Human Genome Project of the 90's, the not insignificant financial outlay is being presented as an investment that will net even bigger returns, both in terms of new technology and a vastly increased understanding of the mind. President Obama is expected to include the multi-billion dollar, decade-long funding in his upcoming budget proposal, and neuroscience research was a topic he addressed specifically in his recent State of the Union address.
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Neurobiology research has a long and storied history at Columbia University and its Medical School in New York, dating back to the groundbreaking work of American neurologist Harry Grundfest 60 years ago. 30 years ago Columbia became one of the first universities to bring together diverse, cross-disciplinary researchers in neighboring labs to study behavior at the cellular, molecular, and systems level. By 2004, when Columbia celebrated its 250th anniversary, university president Lee Bollinger (right) announced the formation of a Mind Brain Behavior Initiative to more productively bring scientists into an even more integrated research effort across not only the two existing New York City campuses, but with an anchor (and crossroads) at the new CU Manhattanville campus then in the active planning stages.
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