The California Institute for Regenerative Medicine (CIRM) awarded two scientists at UC San Diego $2 million each for their innovative research. The first award went to Alysson R. Muotri, PhD, professor in the UC San Diego School of Medicine departments of Pediatrics and Cellular and Molecular Medicine. The funding will support studies of new treatments for Zika. The second award went to Dan Kaufman, MD, PhD, professor of medicine in the Division of Regenerative Medicine. This funding will support the creation an “off-the-shelf immunotherapy” using NK cells to treat refractory or resistant tumors, such as ovarian cancer.
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The National Institute of Health (NIH) awarded the University of Georgia a $2.27 Million grant to study a powerful gene editing tool known as CRISPR-Cas. In nature, CRISPR-Cas is a defense mechanism that single-celled organisms such as bacteria use to ward off attacks from viruses and other invaders. For scientists the CISPR-Cas9 system holds a potential tool to edit precise sequences of DNA and silence the genes that predispose some people to diseases such as cancer, diabetes, cardiovascular disorders and mental illness.
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Researchers at UCLA believe using the patient’s own cells to create stem cells for therapeutic purposes is the future of medicine. A recently published study by scientists at UCLA demonstrates how specialized proteins change the cellular characteristics of skin cells to create induced pluripotent stem cells. These stem cells have the ability to turn into any cell type within the body. Also at UCLA, a clinical trial which uses the baby’s own blood-forming stem cells to treat the immune deficiency condition ADA-SCID, better known as “bubble baby disease,” was recently awarded a $20M grant from the California Institute for Regenerative Medicine.
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Rockefeller University received a $25 million gift from the Robertson Foundation that will be used to create the Robertson Therapeutic Development Fund. This fund will be used to help turn basic research discoveries into new medical therapies by providing support for dozens of Rockefeller projects over the next five years. Research grants ranging from $10,000 to $1 million will be awarded from the fund in order to provide Rockefeller scientists with the resources they need to take exceptionally promising research initiatives through the steps that lead to breakthrough medications, new diagnostic tests or other clinical innovations.
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Washington University School of Medicine in St. Louis is leading an international team studying potential treatments to prevent Alzheimer’s disease. The team recently added a third medicationin this worldwide clinical trial that is already underway. According to the WU School of Medicine news site, the latest investigational drug “is designed to lower production of amyloid beta, a protein that clumps together into plaques damaging neurons in the brain, leading to memory loss, cognitive problems and confusion.”
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The chancellor’s office of Texas A&M University (TAMU) recently funded a $5 million initiative to support mass spectrometry research. As part of this initiative a $1 million grant from the Texas A&M University Research Development Fund will be used to develop a shared mass spectrometry core facility and buy two new mass spectrometers for the College Station campus. One will be a gas chromatography combustion/pyrolysis isotope ratio mass spectrometer and the other will be a high resolution isotope ratio mass spectrometer for clumped isotopes.
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Researchers at Texas Medical Center’s (TCM) Houston Methodist Hospital have invented a way to overcome chemotherapy drug resistance and destroy the deadliest type of brain tumors without destroying the surrounding tissue. This targeted approach combines a “smart drug” with chemotherapy. In animal models of human brain cancer, this smart drug prolonged life by over six fold.
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Malaria and toxoplasmosis are caused by different, yet closely related, apicomplexa parasites. Efforts to eliminate these diseases have met with only partial success. Now the National Institute of Health (NIH) has awarded the University of South Florida (USF) a $2.5 million, five year grant to study a new approach to fighting these diseases by stopping their ability to replicate.
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Currently, doctors have two options when a patient needs a facial bone replaced due to injury or illness, such as cancer. They can take a bone from another part of the body and graft it into place. However, implant morbidity and complications caused by the trauma of multiple surgeries make this option less than ideal. The second option is to graft synthetic materials to the site. However, from time of injury to delivery of the custom implant takes about three to four weeks, which reduces the chances of the patient healing properly. But now a new technology being developed by researchers at Texas A&M’s College of Dentistry may revolutionize the treatment process.
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The University of South Florida announced the creation of a Department of Medical Engineering. This trans-disciplinary department consists of physicians and engineers specializing in chemical and mechanical engineering, biomedicine and nanotechnology. It was established through the collaborative efforts of USF’s College of Engineering and USF’s Health Morsani College of Medicine. The goal is to combine related aspects of engineering and medicine while providing access to real-world health care environments for education and research.
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