Washington University School of Medicine in St. Louis is leading an international team studying potential treatments to prevent Alzheimer’s disease. The team recently added a third medicationin this worldwide clinical trial that is already underway. According to the WU School of Medicine news site, the latest investigational drug “is designed to lower production of amyloid beta, a protein that clumps together into plaques damaging neurons in the brain, leading to memory loss, cognitive problems and confusion.”
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Researchers at the University of Massachusetts Amherst, as part of a multi-institution research team, received $4.8 million in life science funding from the National Cancer Institute as part of a five-year life science grant to research a way to target various diseases including Alzheimer’s, cancer and graft-versus-host disease (GVHD) by changing the function of an enzyme that sets in motion over 100 different protein substrates in the body.
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Researchers at the University of California, Santa Barbara have discovered the age and origin of an E280A gene mutation that has caused early-onset Alzheimer’s in a Columbian family. The family, whose members have had Alzheimer’s with more frequency than most families, was traced to a single founder dating from the 1500’s. The research team sequenced the genomes of more than 100 family members and identified the regions of common ancestry. They then used this information to trace the source of the Alzheimer’s mutation.
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