In what is being hailed as a victory for both scientific research and patients' rights, the Supreme Court ruled unanimously yesterday that human genetic material cannot be patented. The case, Association for Molecular Pathology v. Myriad Genetics, has been working its way through the court system for a number of years now, led by plaintiffs including the ACLU, the American College of Medical Genetics, the American Society for Clinical Pathology, and numerous prominent genetic research scientists. The verdict invalidates the patents Myriad Genetics has held on breast cancer genes BRCA1 and BRCA2 since the 1990's and allows other labs besides theirs to test for mutations in those genes which, when present, strongly indicate a genetic predisposition to cancer. It also means that scientists can move forward in their genetic research without threat of being sued for copyright infringement. While the case was brought against Myriad specifically, the decision to disallow human gene patenting has profound implications for both scientific discovery and individual rights of ownership over our own genetic material.
Tags: 2014, CA, 2013, Bioresearch, gene patenting, cancer research, Southwest, Southwest life science marketing events, Cancer Treatment, San Diego, SDVS, Genetics, UC San Diego, biotech industry, Biotechnology Vendor Showcase
One of the reasons cancer is so successful and difficult to treat is that it uses the body's own systems to proliferate, thrive, and hide from attack. Bioresearch scientists out to target cancer are taking a similar approach, building tiny bio-vehicles for locating tumors that reach their destination without setting off a massive immune system alarm or flooding the whole body with toxic chemicals. A team of biochemists at the University of California San Diego led by Dr. Nathan Gianneschi has developed a nanoparticle that assumes a benign shape to travel covertly through the blood system, then, recognizing a tumor, reassembles via an enzymatic cue into a net to attach itself to the cancerous target.
Tags: 2014, CA, University of California San Diego, 2013, Nanobiotechnology, cancer research, Southwest, California, University of California, San Diego, SDVS, BioResearch Product Faire Event, UCSD, Biotechnology Vendor Showcase
Bioengineers at the University of California San Diego have come up with a novel way of removing dangerous toxins from the bloodstream using biomimetic nanosponges. These tiny clean-up particles work by posing as red blood cells, which serves both to evade the body's immune system response to foreign invaders and to attract the toxins to themselves instead of to actual red blood cells. When the toxins have all attached themselves to the nanosponges, they are processed out through the liver without harming the body. The research into this promising therapy comes out of the Zhang Lab in the Jacobs School of Engineering, where in 2011 they pioneered the red blood cell disguise technology for cloaking cancer drug cocktails, allowing the drugs much more time in the body to target diseased cells. Dr. Liangfang Zhang is also on the research faculty of the UCSD Moores Cancer Center.
Tags: 2014, CA, University of California San Diego, 2013, nanoparticle, Nanobiotechnology, nanotechnology, Nanoscience, Southwest, California, University of California, Cell Research, San Diego, SDVS, UCSD, Biotechnology Vendor Showcase
The California Institute for Regenerative Medicine (CIRM) is a major funding agency for stem cell research in the Golden State. Since voters approved the establishment of the agency in 2004, the CIRM has spent billions on research and facilities with the aim of making California the stem cell capital of the US. Now, in a move to advance that research mission even further, the agency has announced awards of $32M to investigators and stem cell companies to create a biobank of diseased cell lines for the use of researchers around the world. Called the Human Induced Pluripotent Stem Cell (hiPSC) Initiative Awards, the project will generate and ensure the availability of high quality disease-specific hiPSC resources for disease modeling, target discovery and drug discovery and development for prevalent, genetically complex diseases.
Tags: 2014, CA, 2013, Stem cell research, Southwest, California, Los Angeles, Biobank, biobanking, LAVS, San Diego, SDVS, San Francisco, SFVS, UC San Diego, Biotechnology Vendor Showcase, UC San Francisco, CIRM, Parnassus Campus, tradeshow, Mission Bay Campus, Parnassus, Mission Bay, BVS, UC Los Angeles
The tighter funding gets, the more likely it is that young investigators pursuing big ideas will get passed over and science grant money will stay with safer, more established projects. Fortunately there are exceptions to that general rule, including a new program established by the Paul G. Allen Family Foundation specifically to support select pioneering research projects that aim to unlock fundamental questions in biology. They recently awarded investigators from 5 prestigious US universities a total of $7.5M to pursue basic questions about the origins and mechanisms of cellular behavior. One of those 5 Distinguished Investigator awards, for $1.6M, is going to quantitative biologist and recent hire Suckjoon Jun, who works in physics and molecular biology at the University of California San Diego. His project title is "Cell-size control and its evolution at the single-cell level," and includes developing methods to perform long-term directed single-cell evolution experiments, as well as single-cell on-chip manipulation, sequencing, and mathematical modeling.
Tags: 2014, CA, University of California San Diego, 2013, cell biology, Southwest, California, University of California, Cell Research, San Diego, SDVS, Funding, UCSD, Biotechnology Vendor Showcase
The Brain Activity Map project could be the next big federal life science research endeavor, with no less a goal than the mapping of the entire living brain and all its neuronal activity. Like the Human Genome Project of the 90's, the not insignificant financial outlay is being presented as an investment that will net even bigger returns, both in terms of new technology and a vastly increased understanding of the mind. President Obama is expected to include the multi-billion dollar, decade-long funding in his upcoming budget proposal, and neuroscience research was a topic he addressed specifically in his recent State of the Union address.
Tags: 2014, CA, University of California San Diego, 2013, Northeast, University of California Berkeley, New York, Columbia University, Southwest, California, University of California, Berkeley, Neuroscience, San Diego, SDVS, Columbia, BioResearch Product Faire Event, Funding, UCSD, NY, NIH, Columbia University Medical Center, Biotechnology Vendor Showcase, Berkeley Labs, UCBerk
Tags: 2014, CA, University of California San Diego, 2013, Southwest, California, University of California, Autism, Neuroscience, San Diego, SDVS, UCSD, UC San Diego, Research, La Jolla, Biotechnology Vendor Showcase, Southwest Region
The California Institute for Regenerative Medicine (CIRM), California's stem cell agency, has just announced a new round of stem cell research funding totalling more than $69M. $12M of that will go to 5 biomedical scientists at the University of California San Diego, with an additional $4.3M awarded to a researcher at Scripps Institute, and a further $4M to two lab teams at the Salk Institute for Biological Studies. That brings the total for UCSD and its affiliate La Jolla research institutes to $17.5M for this third round of CIRM's Early Translational Awards program, which supports projects that are in the initial stages of identifying drugs or cell types that could become disease therapies. UCSD alone received almost twice as much stem cell research funding in this round as any other public university, including UCSF.
Tags: CA, Stem cell research, Southwest, 2012, Scripps, San Diego, SDVS, UC San Diego, La Jolla, Biotechnology Vendor Showcase, CIRM, San Diego Biotechnology
Following up on our much-read April 2011 blog on Biomedical Building News at UCSD, we are pleased to report that the following UCSD medical facilities have celebrated their grand openings:
Tags: CA, biomedical research, Stem cell research, New research facilities, new science wet labs, Southwest, 2012, San Diego, SDVS, Genomics, UC San Diego, LEED, Biotechnology Vendor Showcase Event, 2011