Lab scientists at the University of Pittsburgh Cancer Institute and UP's Center for Biologic Imaging have recently published an important paper in the Journal of Cell Science that sheds light on a novel method of interrupting mitosis in a cell by effectively depriving its mitochondria of a key protein. The resulting replication stress means cancer cells are stopped from successfully multiplying. Colorful images of the targeted cells actually show them stuck in anaphase trying to divide and subsequently tearing themselves apart. By identifying a compound that carries out this protein interference and disrupts normal mitochondrial fission, researchers have identified a promising therapeutic avenue for halting cancer growth.
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Tags: 2014, 2013, University of Pittsburgh, Pennsylvania, Northeast, Hillman Cancer Center, cancer research, cell biology, Microscopy, UPITT, Cell Research, BioResearch Product Faire Event, PA, NIH, Pittsburgh, Northeast Region
The Parkinson's Disease Biomarkers Program (PDBP) is a recently-formed NIH initiative to advance research into biomarkers for the disease in order to better understand its progress and develop treatments. Some funded projects will focus on statistical analysis tools and data sharing among researchers. Others will examine early clinical manifestations of PD in patients. Still more will involve lab studies, including identification of genetic biomarkers as well as antibodies in the blood and changes in body chemistry. All projects "must inform the etiology, pathogenesis or treatment of PD," according to grant program guidelines. Research supported by the PDBP is being carried out at the 11 Morris K. Udall Centers of Excellence in Parkinson's Disease Research (logo right), directed by the National Institute of Neurological Disorders and Stroke (NINDS) within the NIH.
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Neurobiology research has a long and storied history at Columbia University and its Medical School in New York, dating back to the groundbreaking work of American neurologist Harry Grundfest 60 years ago. 30 years ago Columbia became one of the first universities to bring together diverse, cross-disciplinary researchers in neighboring labs to study behavior at the cellular, molecular, and systems level. By 2004, when Columbia celebrated its 250th anniversary, university president Lee Bollinger (right) announced the formation of a Mind Brain Behavior Initiative to more productively bring scientists into an even more integrated research effort across not only the two existing New York City campuses, but with an anchor (and crossroads) at the new CU Manhattanville campus then in the active planning stages.
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Dr. Robert Kormos at the University of Pittsburgh's McGowan Institute for Regenerative Medicine has secured $13.3 million in funding from the NIH's Heart, Lung and Blood Institute (NHLBI) to carry out a 5-year heart device study in collaboration with researchers at the University of Michigan. Both the University of Pittsburgh Medical Center and Michigan's Center for Circulatory Support are leaders in research on and implantation of artificial hearts (also known as mechanical circulatory support devices).
In 2010, this vendor show on campus at the University of Pennsylvania attracted over 500 academic researchers.
If committing to funding a new research building weren't daunting enough, try doing it on a dense urban campus in an historic neighborhood in our nation's capital. This is the situation of Georgetown University, located in northwest Washington DC on the Potomac River. The Georgetown Independent aptly calls the challenge a "massive logistical nightmare." Yet buildings do go up, and more are always under construction and in the pipeline, as evidenced by the latest Campus Plan submitted by the University to the city's Planning Department yesterday.
Construction crews on Civic Center Blvd. at the University of Pennsylvania have been very busy the past few years, and now Penn Med has an impressive research facility that is filling fast.