Jacques Monod Conference on DNA methylation and demethylation
Conference - Roscoff (Brittany), France
The sequence of the human genome was published in 2003, at a cost of 3 billion dollars. Since then, successive technological advances have brought down the cost of sequencing to a few thousand dollars per human genome. This ease of access to genomic data has ushered a new era in biology. In parallel, experiments on cloning and reprogramming have given ample support to previous notions that the DNA in a cell is somehow « marked ». The nucleus of a differentiated cell can be reprogrammed towards totipotency, but this is a slow and very inefficient process. In contrast, the nucleus of an embryonic stem cell is more amenable to reprogramming. Yet, the two genomes are absolutely identical. The difference, as we know, lies in the epigenetic information carried by the different nuclei. DNA methylation is one of these crucial epigenetic marks. There is irrefutable evidence that DNA methylation controls gene expression, cell fate and is altered in disease.
(Courtesy of Roscoff, France (Finistere, Brittany), via francethisway.com)
JACQUES MONOD CONFERENCE ON DNA METHYLATION AND DEMETHYLATION
Sat, Sep 14, 2013 - Wed, Sep 18, 2013
Roscoff (Brittany), France
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