Inflammasomes in health and disease
Conference - Boston, MA, United States
Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses. The discovery of the inflammasome has led to an explosion in basic research linking the inflammasome to normal host-responses to infection as well as sterile inflammatory diseases such as type 2 diabetes, atherosclerosis and gout. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases have also been uncovered. Collectively, these observations have ignited clinical studies to understand the role of inflammasomes in a variety of human diseases.
This two-day conference will bring together international scientists and clinicians working on the inflammasome today. Topics will range from an overview of the molecular mechanisms of inflammasome activation; the roles of IL-1, IL-18 and pyroptosis in immune defenses, novel effectors of the inflammasome and studies of the role of the inflammasome in infectious and sterile inflammatory diseases.
(Courtesy of Boston, MA, US, via http://www.abcam.com/)
Inflammasomes in health and disease
Mon, Jun 24, 2013 - Tue, Jun 25, 2013
Boston University, Boston, MA, US
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