Conference - Itasca, IL, United States
For decades after its discovery, DNA was believed to be a canonical, right-handed double helix. This belief was shaken by the findings that DNA structure is much more dynamic.In fact, DNA can form an enormous variety of secondary structures, including cruciform-like, left-handed helixes, three and four stranded helices, slip-stranded configurations, etc. Most importantly, repetitive DNA sequences, which are overrepresented in genomic DNA, are particularly prone to structural transitions.
Transient denaturation of the double helix, which promotes these dynamic transitions in DNA structure, occurs during all major DNA transactions, including replication, transcription, and recombination. Studies conducted in many labs worldwide have confirmed that structure-prone DNA sequences are central to the normal functioning of the genome, and they are also responsible for its occasional malfunctioning.
Eaglewood Resort & Spa
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