Transcriptional Architecture and Dynamics of the Mammalian Circadian Clock
TSRI Cell Biology Affinity Group Seminar - La Jolla, California, United States
The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes about 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two bHLH-PAS domain proteins, CLOCK and BMAL1. We have solved the crystal structure of the CLOCK:BMAL1 complex and also have used genome-wide methods to study the transcriptional architecture and chromatin dynamics of the core circadian transcriptional network. These studies haven revealed a surprisingly widespread circadian modulation of RNA polymerase II recruitment, de novo transcription, and chromatin remodeling at the genome level.
Speaker: Joseph Takahashi, Ph.D.
Professor, Chair of the Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas
Host: Dr. Katja Lamia
(Courtesy of the Scripps Research Institute, via Wikipedia, en.wikipedia.org)
Visit the TSRI Cell Biology Affinity Group Seminar Schedule:
http://www.scripps.edu/research/cb_affinity/
Thursday, January 24th, 2013 (3:30 to 4:30 pm)
The W.M Keck Foundation Amphitheater - Beckman Center for Chemical Sciences,
The Scripps Research Institute, La Jolla, California
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