Spotlight on Science Meetings, Conferences and Events brings you information on the following event: Reversible Acetylation in Health and Disease (HDACs) Conference
Epigenetic regulation of the genome has become increasingly important to understanding the etiology and fundamental mechanisms of aging and age-related diseases. Key to epigenetic regulation are two classes of lysine-modifying enzymes, the histone deacetylases (sirtuins and HDACs) and the histone acetyltransferases (HATs). Both classes of enzyme are critical for maintaining youthful gene expression patterns, cell cycle progression, DNA repair, stem cells, mitochondria, cell fate, differentiation, cognition, energy utilization, and the pathogenesis of most age-related diseases. Alterations in sirtuin and HDAC function have been linked to neurodegenerative disorders, muscle wasting, cardiac hypertrophy, cancer, HIV infection, and more generally the process of aging. Several HDAC inhibitors have been approved by FDA to treat various cancers. Small molecule modulators of sirtuins are currently in clinical trials for the treatment of cancers, neuromuscular disorders, inflammatory and metabolic disorders. a thorough understanding of sirtuins and HDACs is required, not merely for understanding the regulation of chromatin structure, gene regulation and protein function, but also because these enzymes are intimately involved in normal and abnormal cellular processes that greatly impact human health. As the only conference dedicated to protein acetylation, this biannual meeting plays an essential role in bringing together more than 40 world leaders and ~120 participants.
50 Big Sky Resort Road
Big Sky, MT
From Sunday, August 06, 2017 to Friday, August 11, 2017