Conference - San Diego, CA, United States
Tumors are composite of many different cellular and non-cellular constituents that surround the malignant cancer cells harboring activating mutations in oncogenes or loss of tumor suppressors that drive tumor growth. The functional contribution of TME constituents such as leukocytes, fibroblasts, endothelial cells (both blood and lymphatic), and other stromal components is evolving. It has been appreciated for some time that TME plays a significant role in disease progression, but the precise function of each constituent remains unknown. A variety of infiltrating immune cells, cancer-associated fibroblasts, and angiogenic endothelial cells play expanding and critical functions in sustaining cell proliferation, evading growth suppressors, promoting survival, activating invasion and metastasis, and reprogramming energy metabolism. Some constituents of the TME are also involved in restraining tumor growth and metastasis. This AACR Special Conference will focus on discussing the emerging concepts in stromal cell and ECM heterogeneity, stromal cell metabolism, early events in carcinogenesis involving contributions from tumor cells and their microenvironment, stress responses to oxygen and nutrient gradients, translational impact of targeting the microenvironment, tumor immunity and immunotherapy. We will also discuss therapeutic opportunities revealed by these innovative and interdisciplinary discoveries.
Organization: American Association for Cancer Research - AACR
For more information, please visit: http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=73#.VnF-tSOezIU
Thu, Jan 07, 2016 - Sun, Jan 10, 2016
Hard Rock Hotel
San Diego, California, USA
