A quick look at top funded nucleome related projects on the NIH funding site reveals that UCSD still holds the number one position in terms of the total number of funding dollars (See table below). The UCSD based project, overseen by ZHONG, SHENG et al. focuses on THE ORGANIZATIONAL HUB AND WEB PORTAL FOR THE 4D NUCLEOME NETWORK.
UCSD continues to lead in this area. We reported in 2015 that the National Institutes of Health had awarded $30 million in grants for the development of the 4D Nucleome Program at University of California, San Diego. That $120 million NIH project comprised six separate initiatives, with three of the initiatives involving UCSD researchers. UCSD’s involvement in the program at that time included a five-year, $20.2 million grant to establish the 4D Nucleome Program organizational hub at the university, to“integrate the efforts of all the 4D Nucleome Program’s funded initiatives and promote cooperation and communication among participants”.
At that time additional 4D Nucleome Program initiatives included a five-year, $8.6 million grant to UC San Diego and Ludwig Cancer Research for the creation of the Nuclear Organization and Function Interdisciplinary Consortium, and a five-year, $3 million grant for Imaging Tools. UCSD research teams will create genetically encoded metal nanoparticles and novel paints that will expose specific genes in the DNA and allow researchers to see their nuclear structure. The analysis and storage of these visual genome atlases will be facilitated by the program’s organizational hub.
|
Title |
PI |
Institution |
Funding |
|
THE ORGANIZATIONAL HUB AND WEB PORTAL FOR THE 4D NUCLEOME NETWORK |
ZHONG, SHENG et al. |
UNIVERSITY OF CALIFORNIA SAN DIEGO |
$4,477,447 |
|
DEKKER, JOB et al. |
UNIV OF MASSACHUSETTS MED SCH WORCESTER |
$2,784,782 |
|
|
4D NUCLEOME NETWORK DATA COORDINATION AND INTEGRATION CENTER |
PARK, PETER J |
HARVARD MEDICAL SCHOOL |
$2,422,164 |
|
UNIVERSITY OF WASHINGTON CENTER FOR NUCLEAR ORGANIZATION AND FUNCTION |
SHENDURE, JAY ASHOK et al. |
UNIVERSITY OF WASHINGTON |
$2,290,679 |
|
SYSTEMS ANALYSIS OF EPIGENOMIC ARCHITECTURE IN CANCER PROGRESSION |
HUANG, TIM H.-M. et al. |
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER |
$1,918,884 |
|
REN, BING et al. |
LUDWIG INSTITUTE FOR CANCER RES LTD |
$1,791,569 |
|
|
COMBINED CYTOLOGICAL, GENOMIC, AND FUNCTIONAL MAPPING OF NUCLEAR GENOME ORGANIZATION |
BELMONT, ANDREW STEVEN |
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN |
$1,616,367 |
|
DEKKER, JOB |
UNIV OF MASSACHUSETTS MED SCH WORCESTER |
$1,273,083 |
|
|
TOOLS FOR IMAGING THE FUNCTIONAL GENOME IN LIVING CELLS AND TISSUES |
SINGER, ROBERT H. et al. |
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC |
$850,000 |
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