Science Market Update

Johns Hopkins Receives $5.1M NIH Grant to Develop Better STD Diagnostic Tool

Posted by Rebecca Inch-Partridge on Thu, Oct 11, 2018

Half of all sexually active young people will acquire a sexually transmitted disease by the age of 25. According to the Center for Disease Ccontrol (CDC) there are 20 million new cases of sexually transmitted infections (STI) each year. There are more than 110 million Americans currently living with a STI. The direct medical cost to the U.S. healthcare system from these infections is nearly $16 billion every year. Researchers at Johns Hopkins University recently received a $5.1 million National Institutes of Health (NIH) grant to develop a faster and more accurate diagnostic tool for STIs. This device could radically change how sexually transmitted infections are tested and treated.

cdc stats gonorrea

(CDC Graph depicting up-swing in gonorrhea cases, especially in those 20-29)  

Currently testing takes between 24 and 48 hours, because the bacteria must be cultured or tested by molecular methods in a lab. This means that many people leave the clinic or emergency room without knowing if they are infected or not. Besides the delay in treatment this causes, the reality is that some patients never follow up. This means they can unknowingly spread the bacteria. This is especially true in the case of gonorrhea because 40% of patients experience no symptoms.

With the NIH funding, Jeff Wang, a professor in the Whiting School of Engineering's Department of Mechanical Engineering, will lead a team that is creating a device that not only rapidly tests for gonorrhea, it also detects if a particular bacterial strain is resistant to antibiotics.

In an article for the Hub, Wang said, "Our diagnostic tool ... analyzes gonorrhea's phenotype, or observable characteristics and behaviors of an organism, and specific DNA markers to detect its antimicrobial susceptibility. The results will tell the physician if a patient is infected, and if so, which medications are best suited for treatment and the minimum amount needed."

Another benefit of the device Wang and his team are working is that it reduces testing time to one hour or less. This allows patients to get their results and begin treatment almost immediately.

Potential Effects of Gonorrhea on Women:

  • pelvic inflammatory disease gonorrhoeae_Bacteria
  • ectopic pregnancies
  • infertility.

In men:

  • Epididymitis
  • systemic infections

Untreated, gonorrhea also increases the chances of getting or spreading HIV in both men and woman. This is because the body sends millions of immune cells to the site of an infection causing inflammation in the area, and as Wang explains,  “The HIV virus invades and replicates inside these immune cells, and because the body keeps sending more immune cells, it serves to set up a continuous cycle of inflammation, essentially 'feeding' the HIV virus."

For this project Wang, a member of the school's Institute for NanoBioTechnology, has teamed up with Charlotte Gaydos, director of the Johns Hopkins Center for the Development of Point-of-Care Tests for Sexually Transmitted Diseases. In the same article Gaydos states, “...receiving results right away and knowing resistance susceptibility allows us to create precision-directed therapy... This means we can save some of the stronger medications for when they are really needed.” In contrast the current uniform approach to treatment is believed to increase antimicrobial resistance.

This year, to date, Johns Hopkins has been awarded 1,316 grants from the NIH, totaling $662,667,284. Laboratory supply companies wishing to market to the well funded researchers at Johns Hopkins University should plan on participating at the first annual bioresearch product faire hosted by Biotechnology Calendar Inc. This event, which allows researchers to meet face to face with lab suppliers to discuss their needs, will be held on Friday, March 15, 2019.    

Johns Hopkins

To find out how this biotech trade show can increase your 2019 sales contact our knowledgeable staff at (530) 272-6675. 

To find out about our other biotechnology vendor showcases in the coming year, click on the link below.    

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Tags: Johns Hopkins University, Baltimore, new research grant, STD Research, BioResearch Product Faire, Bacterial Cell Research, nih research funding, university research funding, Kansas research

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