Science Researcher Update: Spotlight on Meetings, Conferences, and Events

4th Annual “Induced Pluripotent Stem Cells: Production & Utility in Regenerative Medicine & Other Applications"

Posted on May 30, 2013 12:10:00 PM

4th Annual “Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine and Other Applications "

Conference - London, United Kingdom

This 4th Annual event will review the drawback and advantages of hIPSCs for diverse type of clinical applications.

Faithfully recapitulating human physiology “in a dish” from a renewable source remains a holy grail for medicine and pharma. Many procedures have been described that, to a limited extent, exhibit human tissue specific function in vitro. In particular, incomplete cellular differentiation and/or the loss of cell phenotype post-differentiation play a major part in this void. We have developed an interdisciplinary approach to address this problem, employing skill sets in cell biology, materials chemistry and pharmacology. Pluripotent stem cells were differentiated to hepatocytes before being re-plated onto a synthetic surface. Our approach yielded metabolically active hepatocyte populations that displayed stable function for over two weeks in vitro. Although metabolic activity was an important indication of cell utility, the accurate prediction of cellular toxicity in response to specific pharmacological compounds represented our goal. Therefore, detailed analysis of hepatocellular toxicity was performed in response to well defined compounds and compared to primary human hepatocytes. Importantly, stem cell derived hepatocytes displayed equivalence to primary human material. Moreover, we demonstrated that our approach was capable of modelling metabolic differences frequently observed in the population.


(Courtesy of The Royal College of Pathologists, via

This event is part of the 2013 Euroscicon Stem Cell Trilogy.  To find out more see

Tuesday, 04 June 2013 (09:00 - 17:00)

The Royal College of Pathologists, Carlton House Terrace
London SW1Y 5AF, United Kingdom

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Tags: 2013, June, Stem cell research, Biotechnology Current Events, United Kingdom, London, Research Meeting UK, Life Sciences, Biotechnology, Stem Cell, Life Science Event

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