Conference - London, United Kingdom
This 4th Annual event will review the drawback and advantages of hIPSCs for diverse type of clinical applications.
Faithfully recapitulating human physiology “in a dish” from a renewable source remains a holy grail for medicine and pharma. Many procedures have been described that, to a limited extent, exhibit human tissue specific function in vitro. In particular, incomplete cellular differentiation and/or the loss of cell phenotype post-differentiation play a major part in this void. We have developed an interdisciplinary approach to address this problem, employing skill sets in cell biology, materials chemistry and pharmacology. Pluripotent stem cells were differentiated to hepatocytes before being re-plated onto a synthetic surface. Our approach yielded metabolically active hepatocyte populations that displayed stable function for over two weeks in vitro. Although metabolic activity was an important indication of cell utility, the accurate prediction of cellular toxicity in response to specific pharmacological compounds represented our goal. Therefore, detailed analysis of hepatocellular toxicity was performed in response to well defined compounds and compared to primary human hepatocytes. Importantly, stem cell derived hepatocytes displayed equivalence to primary human material. Moreover, we demonstrated that our approach was capable of modelling metabolic differences frequently observed in the population.
(Courtesy of The Royal College of Pathologists, via en.wikipedia.org)
Tuesday, 04 June 2013 (09:00 - 17:00)
The Royal College of Pathologists, Carlton House Terrace
London SW1Y 5AF, United Kingdom
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