Science Market Update

UC Davis Researchers Find Promising Treatment for Huntington’s

Posted by Cat Girton on Thu, Apr 07, 2016

An estimated 30,000 people in the United States are afflicted with Huntington’s disease. Receiving a diagnosis of this genetic neurodegenerative disorder is unimaginably devastating. Sufferers slowly lose control of their movement and develop psychiatric problems over the course of 10-25 years, and often the disease is undetected until adulthood. Just this year, UC Davis researchers in Sacramento, California have discovered that human mesenchymal stem cells (MSCs) - cells with the ability to differentiate into bone cells, muscle cells, and other cell types - could be the key to developing an effective new therapy to treat Huntington’s. The promising findings are published in the journal Molecular Therapy

The mechanism of Huntington’s disease is an abnormality in the huntingtin gene, which causes an overabundance in the brain of a mutated protein, mHtt. A high concentration of this protein interferes with the expression and transport of a key brain growth factor, BDNF, resulting in the death of cells in a particular area of the brain. Earlier methods of replacing BDNFNeuron with mHTT inclusion have not proven to be effective, or result in other problems throughout the body. Recently the Davis research team, led by principal investigator Vicki Wheelock, has developed a new and much more feasible approach.

“For the first time, human stem cells have been successfully used as a platform to deliver brain-derived neurotrophic factor (BDNF), the growth factor that shows great promise for treating Huntington’s disease,” said Wheelok, clinical professor of neurology and director of UC Davis’s Huntington’s Disease Center of Excellence Clinic.

The advantage of using MSCs to deliver BDNF is that they are not rejected by the immune system (even if they are donor cells), they are drawn to regions of injury, and they promote cell growth and neuron interactions. “MSCs act as ‘paramedic delivery trucks’ that move through damaged brain tissue, delivering factors that promote healing and new growth,” explained Jan Nolta, co-principal investigator and director of the UC Davis Stem Cell Program and its Institute for Regenerative Cures in Sacramento. “They are an excellent platform for delivering growth factors or other therapeutic agents.”

UC Davis Medical CenterThis study was performed on bioengineered mice. MSCs from healthy human bone marrow were engineered to overproduce BDNF, and then injected into the brains of mice bred with a mutation mirroring human Huntington’s. The MSC injection proved to be a success – the findings showed evidence of elevated neuron growth activity, and positive behavioral changes were observed. In addition, the mice receiving human MSCs lived up to 15 percent longer.

This is very encouraging news for human sufferers, though more mouse and large animal studies are needed before the therapy will be cleared for human trials. However, in the future, this new method of BDNF delivery could help those afflicted with Huntington’s to live years longer and with increased brain function.

The study was funded by a five-year, multi-million dollar award from the California Institute for Regenerative Medicine (CIRM) granted to Davis researchers to develop a cellular therapy for Huntington’s disease. In addition, the research team received financial support from the National Institutes of Health (NIH), the National Science Foundation, and philanthropic donors.

UC Davis Medical Center and associated centers commonly receive generous grants and awards to support their cutting-edge medical research. UC Davis received over $500M for R&D in 2014 (their most recently reported year).

This top research institution is a prime marketplace for lab suppliers. This is why Biotechnology Calendar, Inc. is presenting an opportunity to meet face-to-face with 150 Davis life science professionals.

BioResearch Product Faire™ - University of California, Davis Medical Center – 6/7/2016

Life science researchers at a biotechnology product faire at UC Davis Medical Center

If you’re interested in exhibiting your company’s lab products and services to these active researchers, who are in constant need of the newest lab tools, visit the link below:

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If you are a researcher wanting to discover exciting new lab equipment and technologies, visit this link to register for this no-cost event: 

UCDMC  Researchers

 

Interested in reaching two well-funded California research markets? Be sure to consider exhibiting at our UC Berkeley vendor show, taking place the very next day. 

Tags: Lab Product show, Stem cell research, Neuroscience, UC Davis - Medical Center, Huntington's Disease

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