Course - Cold Spring Harbor, NY, United States
Crystallography and X-ray diffraction yield a wealth of structural information unobtainable through other methods. This intense laboratory/computational course focuses on the major techniques used to determine the three-dimensional structures of macromolecules. It is designed for scientists with a working knowledge of protein structure and function, but who are new to macromolecular crystallography. Topics to be covered include basic diffraction theory, crystallization (proteins, nucleic acids and complexes), crystal characterization, X-ray sources and optics, synchrotrons, Cryocrystallography, data collection, data reduction, heavy atom substructure determination, multiple isomorphous replacement, single and multiwavelength anomalous diffraction, molecular replacement, solvent flattening, non-crystallographic symmetry averaging, electron density interpretation, molecular graphics, structure refinement, structure validation, coordinate deposition and structure presentation.
Organization: Cold Spring Harbor Laboratory
X-Ray Methods in Structural Biology
Mon, Oct 13, 2014 - Tue, Oct 28, 2014
CSHL Campus
Cold Spring Harbor, United States
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