Pharmaceutical Microscopy Workshop: Polymorphism

The choice of the optimum solid-state form is critical for successful pharmaceutical development. Broadly defined, form includes polymorphs, hydrates, solvates, salts, co-crystals etc.  Microscopy is well- suited to the study of solid-state form.

This workshop covers the use of the microscope in both early pharmaceutical development when the form is chosen and in later stages of development where the form is monitored for stability.

The material in this workshop is broadly separated by development phase into form discovery and form understanding. Form discovery usually occurs before first time in human (FTIH) into Phase 1. Form understanding generally occurs in Phase 1 and Phase 2, although some work extends into Phase 3.

This workshop emphasizes the role of microscopy in each aspect of form understanding. Although we will discuss solid-state theory and fundamentals, the workshop relies heavily on case studies, demonstrations, and instrument usage.