Science Researcher Update

Transcriptional Architecture and Dynamics of the Mammalian Circadian Clock Seminar

Written by BCI Staff | Jan 19, 2013 9:02:00 PM

Transcriptional Architecture and Dynamics of the Mammalian Circadian Clock

TSRI Cell Biology Affinity Group Seminar - La Jolla, California, United States

The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes about 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two bHLH-PAS domain proteins, CLOCK and BMAL1.  We have solved the crystal structure of the CLOCK:BMAL1 complex and also have used genome-wide methods to study the transcriptional architecture and chromatin dynamics of the core circadian transcriptional network.  These studies haven revealed a surprisingly widespread circadian modulation of RNA polymerase II recruitment, de novo transcription, and chromatin remodeling at the genome level. 

Speaker: Joseph Takahashi, Ph.D.
Professor, Chair of the Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas

Host: Dr. Katja Lamia

(Courtesy of the Scripps Research Institute, via Wikipedia, en.wikipedia.org)

Visit the TSRI Cell Biology Affinity Group Seminar Schedule:
http://www.scripps.edu/research/cb_affinity/

Thursday, January 24th, 2013 (3:30 to 4:30 pm)
The W.M Keck Foundation Amphitheater - Beckman Center for Chemical Sciences,

The Scripps Research Institute, La Jolla, California

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