Transcriptional Architecture and Dynamics of the Mammalian Circadian Clock
TSRI Cell Biology Affinity Group Seminar - La Jolla, California, United States
The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes about 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two bHLH-PAS domain proteins, CLOCK and BMAL1. We have solved the crystal structure of the CLOCK:BMAL1 complex and also have used genome-wide methods to study the transcriptional architecture and chromatin dynamics of the core circadian transcriptional network. These studies haven revealed a surprisingly widespread circadian modulation of RNA polymerase II recruitment, de novo transcription, and chromatin remodeling at the genome level.
Speaker: Joseph Takahashi, Ph.D.
Professor, Chair of the Department of Neuroscience, UT Southwestern Medical Center, Dallas, Texas
Host: Dr. Katja Lamia
(Courtesy of the Scripps Research Institute, via Wikipedia, en.wikipedia.org)
Visit the TSRI Cell Biology Affinity Group Seminar Schedule:
http://www.scripps.edu/research/cb_affinity/
Thursday, January 24th, 2013 (3:30 to 4:30 pm)
The W.M Keck Foundation Amphitheater - Beckman Center for Chemical Sciences,
The Scripps Research Institute, La Jolla, California
If you'd like to ask a question or post a comment about this talk please do so below.
This seminar posting is brought to you by Biotechnology Calendar, Inc. providing access to research information and research tools for nearly 20 years. Visit our Science Market Update Blog for current science funding and market information or see our schedule of upcoming science research laboratory product shows.