Conference - London, United Kingdom
The aim of this meeting is to provide an overview of these three families of receptors and provide the most recent advances in the area of innate immune pattern recognition.
Transcriptome analysis of cigarette smoke extract induced TLR2-dependent activation of human cells.
Dr Mark Paul-Clark, National heart and Lung Institute, London, UK
Smoking cigarettes causes approximately 5 million deaths world wide each year, and is a risk factor for a number of chronic diseases. We have previously shown that oxidants and cigarette smoke extract (CSE) activate cells in vitro and in vivo, in part via the pattern recognition receptor TLR2. We transfected HEK293 cells with TLR2/6 or control vector were treated with H2O2, CSE and control media for 8h. Expression patterns in HEK293 cells were similar to those obtained from THP-1 cells and PBMCs. Pathway analysis of these cells revealed that inflammation was associated with NRF2-mediated and aryl hydrocarbon receptor signaling pathways.
(Carlton House Terrace, via forum.skyscraperpage.com)
Thursday, 26 September 2013 (09:00 - 17:00)
The Royal College of Pathologists - 2 Carlton House Terrace, London, SW1Y 5AF, United Kingdom
Contact: Dr Shara Cohen (enquiries@euroscicon.com)
Phone: 07507 799380
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