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Genetics of Complex Human Diseases

Course - Cold Spring Harbor, NY, United States

Complex diseases are conditions that are influenced by the actions of multiple genes, their interactions with each other and with the environment. This lecture course will consider the difficulties in studying the genetic basis of complex disorders such as diabetes, cardiovascular disease, cancer, Alzheimer's disease, schizophrenia and epilepsy. We will discuss genetic-epidemiologic study designs, including family, twin, case/control and adoption studies, as well as methods for quantifying the strength of the genetic influences on a disease. A major focus will be the identification of specific gene effects using both linkage and association analysis and their variants. We will discuss the efficiency and robustness of different designs for such analysis and how evidence from epidemiologic studies informs both the design and interpretation of molecular genetic studies. Study design and methods for analysis of quantitative risk factors related to complex diseases will be covered as well as hapiotype mapping, SNP tagging, meta-analysis and gene-environment interaction. An overview of high throughput laboratory methods will be given to provide participants with insight into the applications of these techniques. Illustrations will be provided through discussion of results from ongoing studies of a variety complex diseases and related risk factors.

(Photo courtesy of http://www.cshl.edu/meetings)

Tue, Aug 07, 2012 - Mon, Aug 13, 2012

Cold Spring Harbor Laboratory Meetings & Courses Program, 1 Bungtown Road, Cold Spring Harbor, NY 11724

Contact:  (meetings@cshl.edu)
Phone: 516 367 8346

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