Conference - Dublin, Ireland
In the past 3 years there has been an upsurge of interest amongst immunologists and inflammation biologists on metabolic changes occurring in cells of the immune system which determine their activation state.The complexity of the metabolome is yielding somewhat, with very important and interesting findings being made on specific metabolic changes occurring in cell types such as macrophages, dendritic cells and T lymphocytes. What is especially interesting is a shift towards glycolysis being a hallmark of inflammatory cell types such as M1 macrophages and Th17 cells, while oxidative metabolism appears to have a more important role in cells involved in the anti-inflammatory process, such as Treg cells and M2 macrophages. Memory T cells also appear to favor oxidative metabolism, shifting to glycolysis when transiting into effector cells. Metabolites are therefore of interest, not just in the generation of ATP and for biosynthetic intermediates, but also as actual signals determining the phenotype of the cell. Exciting new insights are being uncovered into the role of such diverse agents of metabolism as the enzyme GAPDH, the transcription factor HIF1alpha, amino acids, mTOR, AMP kinase, succinate, citrate and NAD+. There is an imperative that immunologists learn about these developments since it is becoming evident that the findings being made will impact on all aspects of host defence and inflammation. Insights into the pathogenesis of inflammatory and infectious diseases are also emerging providing new options for therapeutic intervention. This conference will bring together the world’s pioneers in this area for what promises to be a highly informative and stimulating conference.
Organization: Abcam Events
Thu, May 29, 2014 - Fri, May 30, 2014
The Trinity Biomedical Sciences Institute
Pearse Street, Dublin 2, Ireland
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