Histone Deacetylases and Sirtuins in Biology, Disease and Aging

 

Conference - Timmedorfer Strand, Germany

 

This FASEB Science Research Conference (SRC) focuses on Histone deacetylases (HDACs) as vital regulators of fundamental cellular events, including cell cycle progression, stem cell functions, cell fate determination, cell differentiation, many diseases and even aging. New technologies are being rapidly developed to identify and quantify these post-translational modifications. Importantly, small molecule HDAC inhibitors and activators are currently in clinical trials for the treatment of leukemia and lymphoma, solid tumors, neuromuscular disorders, metabolic disorders. One exciting group of deacetylases covered by the conference is the Sirtuins, which delay more than a dozen different diseases, to reverse aspects of aging, and extend lifespan in rodents. For example resveratrol, a sirtuin activator and one of the components in red wine that has been linked to increased health and lifespan in humans. Synthetic sirtuin activators that are 1000 times more potent than resveratrol have extended lifespan in mice and are now in clinical trials. New ways to activate Sirtuins (e.g. NAD precursors, CD38 inhibitors) are emerging as exciting new approaches to treating diseases. Thus, a thorough understanding of HDACs is required, not merely for understanding the regulation of chromatin structure, gene regulation and protein function, but also because HDACs are intimately involved in normal and abnormal cellular processes that greatly impact human health. This meeting will foster rapid exchange of the most recent findings and concepts on HDACs, HATs and lysine modification. A session on drug development and clinical results will disseminate information about the latest advances in human research and in industry.

Organization: FASEB

Histone Deacetylases and Sirtuins in Biology, Disease and Aging

 

If you'd like to ask a question or post a comment about this talk please do so below.