Conference - Ashburn, VA, United States
Synaptic vesicles, the secretory organelles that store and secrete non-peptide nuerotransmitters, have been extensively characterized. Yet, how these organelles are generated and regenerated during repeated cycles of exo-endocytosis remains poorly understood. While strong evidence implicates clathrin-mediated budding in their formation after each cycle of exocytosis, the precise steps leading from a newly formed clathrin coated vesicle to a new, neurotransmitter filled, synaptic vesicle and the role of endosomal intermediates remain unclear. Clathrin-independent pathways of endocytosis are thought to operate in parallel with clathrin-mediated endocytosis. Mechanisms underlying the incorporation of key membrane proteins (in a roughly defined stoichiometry relative to each other) in synaptic vesicles and those that determine their very small and highly homogenous shape are largely unknown. It is anticipated that an answer to these questions will not only advance knowledge of mechanisms in synaptic transmission, but also have broad implications in the field of membrane transport. The goal of the workshop is to bring together investigators from different fields to foster discussion, interactions and potential collaborations.
(Courtesy of Recent insights into the building and cycling of synaptic vesicles, via sciencedirect.com)
Conferences | Janelia Farm Research Campus
October 13-16, 2013
Janelia Farm Research Campus, Ashburn, VA, US
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