Targeting Epigenetic Regulators for Cancer Therapy
Symposium - New York City, United States
The highly coordinated activities of epigenetic regulators, such as histone acetyltransferases (HATs)*, methyltransferases, and chromatin-remodeling enzymes, are essential for controlling and maintaining normal gene expression patterns in humans. Deregulation of these epigenetic regulators, however, results in aberrant gene expression consequently leading to cancer and other diseases. Thus, in the past decade it has become increasingly clear that the heritable alterations in cancer cells occur not only at the level of the primary DNA sequence but also at the level of the cancer epigenome. As advanced understanding of how alterations in specific epigenetic regulators lead to malignant cellular transformation, increasing efforts have been put forth to identify drugs that may inhibit the aberrant activities of these epigenetic regulators with the hopes of reversing the disease state. Indeed, anticancer drugs targeting DNA methyltransferases and histone deacetylases (HDACs)* have successfully demonstrated antitumor activity in the clinic, as exemplified by the HDAC inhibitor Vorinostat approved by the FDA in 2006. More recently reports on the roles of the bromodomain-containing BET family members and methyltransferase EZH2 in driving cell growth and survival have provided further validation of epigenetic regulators as critical drivers of the transformed cancer cell phenotype.
In this symposium, will be reviewed the advances made in understanding the roles of epigenetic regulators in cancer development and the progresses towards designing effective treatments targeting the epigenome.
(Courtesy of Epigenetic cancer therapy, via readcube.com)
Targeting Epigenetic Regulators for Cancer Therapy | The New York
Fri, May 24, 2013 - Fri, May 24, 2013 (8:30 AM - 4:30 PM)
New York Academy of Sciences
250 Greenwich Street, 40th Floor, New York City, NY, United States
If you'd like to ask a question or post a comment about this talk please do so below.
This seminar posting is brought to you by Biotechnology Calendar, Inc. providing access to research information and research tools for nearly 20 years. Visit our Science Market Update Blog for current science funding and market information or see our schedule of upcoming science research laboratory product shows.