Science Researcher Update

The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells & Cancer

Written by BCI Staff | May 16, 2013 2:51:00 PM

The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer

Conference, Symposium - Monterey, CA, United States

Over the past several years, the Hippo tumor suppressor pathway has emerged as a complex signaling network that has significant implications for our understanding of the molecular mechanisms of cancer development and stem cell biology. The main effectors of this pathway, YAP and TAZ, are transcriptional co- activators, which act as stemness factors and potent oncogenes. Recent studies have revealed that abnormal expression of components of the network can lead to cancer. Therefore, the pathway and its networking molecules are attractive targets for the development of cancer drugs and unconventional therapeutic interventions. Several paradoxes have emerged in the field in recent years, and fast progress in this field is due, in large part, to an active dialog between Drosophila geneticists and mammalian signalers. The overwhelming interest of researchers in the function of the Hippo pathway in stem cells and cancer prompted us to seek a larger forum. At the Keystone Symposia meeting on The Hippo Tumor Suppressor Network we aim to: (i) Define why YAP and TAZ function as either oncogenes or tumor suppressors; (ii) Identify membrane complexes, which activate the Hippo pathway in mammals, as the orthology with the fly receptors is not clear; (iii) Define targets for small molecule inhibitors and activators within pathway components based on structured modules, including WW, PDZ and SARAH domains. The meeting will be unique in bringing together Drosophila geneticists, basic and clinical cancer researchers, and the stem cell research community. We anticipate that this meeting will help to consolidate the emerging field and have an impact on development of new cancer therapies

(Courtesy of how immune cells can promote cancer progression, via info.sanguinebio.com)

The content above is taken from the event website, more information available here.

Sunday, May 19, 2013 – Thursday, May 23, 2013

Hyatt Regency Monterey, Monterey, CA, United States

Contact email: (info@keystonesymposia.org)

  If you'd like to ask a question or post a comment about this talk please do so below.

This seminar posting is brought to you by Biotechnology Calendar, Inc. providing access to research information and research tools for nearly 20 years. Visit our Science Market Update Blog for current science funding and market information or see our schedule of upcoming science research laboratory product shows.