Cells on Chips: From Single Cell Studies Towards Tissue Engineering
Workshop - Bordeaux, France
Cell differentiation, morphogenesis, proliferation or apoptosis are highly dependent on interactions between the cell and its environment. These biological mechanisms are induced by interactions with neighboring cells or extracellular matrix. Besides the classical biochemical signaling, physical properties and mechanical stress exerted by the environment play a significant role in the physiology and fate of cells. The latest developments in micro-nanotechnologies and the development of novel lab-on-a-chip can recreate artificially microfluidic environments mimicking the complex geometry (2D and 3D) and biochemical extracellular matrix. It is therefore possible to generate various mechanical and biochemical stimuli acting on a cell or tissue with excellent spatial and temporal control. The objective of this workshop is to introduce various technological approaches combining simple chemical and topographical patterning at a subcellular scale to get relevant insights into the laws governing the phenomena of mechanotransduction, morphogenesis, apoptosis, etc. It will also describe the strategies currently used in the field of biochips for celle diagnosis but also to recreate artificially, in vitro from stem cells, tissues in a given differentiated state.
Mon, Sep 24, 2012 - Tue, Sep 25, 2012
Bordeaux, France
101, rue de Tolbiac
75654 Paris Cedex 13 – France
Contact: ateliers@inserm.fr
Tel.: 33 (0)1 44 23 62 04 / 62 03
Fax: 33 (0)1 44 23 62 93
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