Regulated Proteolysis of Cell Surface Proteins
Conference - Ventura, CA, United States
Sheddases and Intramembrane-Cleaving Proteases: From Basic Research to Clinical Applications.
Regulated proteolytic release of proteins from the membrane provides cells with information essential for controlling cell fate specification, maintaining organelle homeostasis, and sustaining tissue-specific functions. Genetic dysregulation of membrane proteolysis underlies many pathologies including Alzheimer’s disease, Parkinson’s disease, allergies, obesity, cardiac hypertrophy, inflammation, cancer and autoimmune diseases. Some of the world’s deadliest pathogens also rely upon these proteolytic cascades to infect hosts, causing diseases including malaria, tuberculosis, cholera and hepatitis C virus infection. Thus many members of the sheddase and intramembrane protease families are attractive targets for potential therapeutic intervention in dozens of diseases. Key sheddases include members of the A Disintegrin And Metalloproteinase (ADAM) family, meprins, and the aspartyl proteases beta-secretase (BACE1) and its homolog BACE2. Upon release of ectodomains by sheddases, the membrane-bound remnants are often cleaved by membrane-embedded proteases, which include the presenilin-containing gamma-secretases, signal peptide peptidases, and S2P families. These proteases contain multiple transmembrane domains, and their active sites reside within the boundaries of the lipid bilayer. Proteolysis within the transmembrane region of the substrate leads to release of the cytoplasmic domain, which in some cases can translocate to the nucleus and regulate transcription. Rhomboid intramembrane proteases release factors to the outside of the cell, often regulating cell signaling or adhesion. Focusing efforts on these various membrane proteolytic reactions as master regulators that impact major physiological and pathologic conditions, this meeting will bring together experts from diverse disciplines to discuss frontier projects, emerging experimental strategies and most recent advancement in understanding sheddase and intramembrane protease activities in health, disease, and therapy.
Organization: GRC
(Courtesy of Four Points Sheraton / Holiday Inn Express, Ventura, CA, US, via fourpointsventuraharborresort.com)
Regulated Proteolysis of Cell Surface Proteins
Sun, Mar 30, 2014 - Fri, Apr 04, 2014
Four Points Sheraton / Holiday Inn Express
Ventura, CA, United States
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