“Nuclear Mechanotransduction & Genome Regulation”
Seminar - Sanford-Burnham Medical Research Institute
Mechanical signals from the extracellular matrix impinge on cellular geometry resulting in altered functional nuclear landscape and gene expression programs. These alterations regulate diverse biological processes including stem-cell differentiation, developmental genetic programs and cellular homeostasis. How such signals are integrated to the 3D spatio-temporal organization of the cell nucleus to elicit differential gene expression patterns are poorly understood. To investigate the biophysical principles underlying these processes, we use a multi-disciplinary approach, combining high resolution imaging of live-cells cultured on micro-patterned substrates, single-cell mechanics and genomics. I will describe some of our ongoing work that is beginning to provide quantitative and modular links between cell geometry and nuclear mechanics in regulating 3D chromosome organization and genetic information.
Speaker: G.V. Shivashankar, Ph.D., Deputy Director, Mechanobiology Institute, Singapore &
Associate Professor, Dept. of Biological Sciences, National University of Singapore
Host: Dorit Hanein, Ph.D.
(Courtesy of Sanford-Burnham Medical Research Institute's logo, via https://mail.google.com/)
For more information, please visit: http://www.sanfordburnham.org/pages/calendar.aspx
Tuesday, January 7, 2014 12:00 pm (PT) / 3:00 pm (ET)
Sanford-Burnham Medical Research Institute
Fishman Auditorium, La Jolla A1330, CA, Lake Nona, FL, US
Contact: Laura Nelson (lnelson@sanfordburnham.org)
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