Science Market Update

UCSF Stem Cell Research Advances with Brain Cell Mouse Transplants

Posted by Jaimee Saliba on Fri, May 10, 2013

Researchers at the Broad Center of Regeneration Medicine and Stem Cell Research on the Parnassus Campus of the University of California San Francisco have just published the results of two related studies involving differentiated brain cells transplanted into mice. In one case, the cells were human brain cells integrated successfully into a mouse brain; in the other, epileptic mice were cured with specialized mouse brain cells. In both studies the differentiated cells were a type of interneuron progenitor called medial ganglionic eminence (MGE) cells.  Unlike other brain stem cells that can turn into any number of specialized cells, these differentiated MGE cells have a specific function, which is to inhibit signaling in overactive nerve circuits. These experiments hold promise for future treatment of neurological disorders like Parkinson’s disease, Alzheimer’s, epilepsy, and the chronic pain and spasticity caused by spinal cord injury.

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Tags: 2014, CA, University of California San Francisco, 2013, University of California San Francisco Mission Bay, University of California San Francisco Parnassus, Parkinson's Disease Research, Southwest, California, University of California, brain research, San Francisco, SFVS, Biotechnology Vendor Showcase, UCSF, Parnassus, Mission Bay

Penn Parkinson's Research Center Part of New NIH Biomarkers Initiative

Posted by Jaimee Saliba on Fri, Jan 18, 2013

The Parkinson's Disease Biomarkers Program (PDBP) is a recently-formed NIH initiative to advance research into biomarkers for the disease in order to better understand its progress and develop treatments. Some funded projects will focus on statistical analysis tools and data sharing among researchers. Others will examine early clinical manifestations of PD in patients. Still more will involve lab studies, including identification of genetic biomarkers as well as antibodies in the blood and changes in body chemistry. All projects "must inform the etiology, pathogenesis or treatment of PD," according to grant program guidelines. Research supported by the PDBP is being carried out at the 11 Morris K. Udall Centers of Excellence in Parkinson's Disease Research (logo right), directed by the National Institute of Neurological Disorders and Stroke (NINDS) within the NIH.

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Tags: 2014, 2013, Pennsylvania, Northeast, University of Pennsylvania, UPenn, Thomas Jefferson University, Parkinson's Disease Research, Biomarkers, Philadelphia, BioResearch Product Faire Event, Funding, Genomics, Neurology, NIH, Northeast Region, ThomJeff