Researchers from UCLA and partnering schools guided by Laurent Bentolila found evidence supporting the spread of malignant cells through angiotropism with vascular co-option, and even suggested they may be related or identical processes. These findings were published in Nature Scientific Reports. With angiotropism being the ability for cells to travel along surface of blood vessels, but not be inside of them, also called extravascular migratory metastasis (EVMM) and vascular co-option being the ability for a tumor to use a blood supply and travel along it, this means cancer has an outlet to spread outside of the bloodstream. The spread outside of the bloodstream means some current methods of treating cancer would be ineffective.
“... if the metastasizing cells are on the outside of the blood vessels, they escape exposure to the treatment and continue to spread cancer.”
-Laurent A. Bentolila
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A team of biochemists at UCLA have created a novel system of converting glucose into highly useful chemical compounds, such as those needed to create biofuels and pharmaceuticals. Previous research endeavors relied on using cells to convert sugar into desired compounds. This has been difficult to achieve because cells would rather use sugar for their own natural uses, such as building proteins and cell walls. The UCLA biochemists have recently developed a way to achieve the conversion of glucose into desired compounds- without using cells.
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When vital organs in the body, such as the lungs, begin to fail, an organ transplant can be a solution to the problem. However, receiving a transplant may have its own complications, such as the body rejecting its new organ.
Now, thanks to a generous donation of $1 million dollars from Michael and Linda Keston, researchers from the Division of Pulmonary and Critical Care Medicine at the UCLA David Geffen School of Medicine will be able to continue studying lung disease and the organ rejection commonly following a transplant.
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Like any living organism, cancer cells rely on fuel in order to survive and grow. Unfortunately for many, the growth of cancer cells is extremely deleterious to human health. That is why a major facet of cancer research currently involves locating and preventing the mechanism for fueling cancer cells.
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Six teams of researchers from leading univerisites are going to receive a set of three-year grants, totaling over $7.5 million, to create lab-grown brain cells in a process called neuronal maturation.
The funding to the various universities was made possible by The Paul G. Allen Family Foundation as part of its Allen Distinguished Investigator grants, and will ensure the continued development of important neuroscience research.
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While not necessarily always the best course of treatment, the majority of men with prostate cancer will go with radiation treatment when confronted with options for treating the potentially deadly disease. Unlike other options, including surgery and chemotherapy, radiation treatment is a relatively “outpatient” procedure - with no anesthetic needed, targeted effectiveness, and relatively few short term side effects.
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The sciences of medical care, medical teaching and bioresearch at University of California, Los Angeles have received a boost in the form of an unrestricted gift of $50 million. Given to the David Geffen School of Medicine at UCLA from the estate of Irma and Norman Switzer, the gift was announced Nov. 12 at a gathering of faculty, staff members, the school’s board of visitors and friends of the Switzer family.
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Biochemists at the University of California, Los Angeles recently developed the largest molecular "cage" ever created. This "cage", a cube-like structure, was constructed from 24 copies of a single protein that has the ability to self-assemble into a cage. This newly created cage could potentially lead to new ways of delivering vaccines to infected cells.
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To get under the skin of a tumor is a very difficult task. If the goal is to invade tumor cells, then classic drugs are simply too large to get through. A bioresearch team at the University of California, Los Angeles is collaborating with a startup company to develop particles small enough for the job.
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This June, we saw that Ann Arbor researchers were adjusting the process of cell autophagy in order to fight cancerous tumors. (You can read our article on the subject here.) This September, life scientists at the University of California, Los Angeles have found that tapping into autophagy may prevent the inevitable: that is, the aging of the human body.
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