Science Market Update

UAB Scientists Uncover TNT in Fight Against TB

Posted by Robert Larkin on Mon, Oct 12, 2015

Tuberculosis is a terrible disease that is characterized by a bad, sometimes bloody cough, and which could lead to other serious health problems, or even death.

Over 1.5 million people currently die from TB each year, and as many as one third of the world’s population is currently infected, according to the Centers for Disease Control and Prevention.

In an effort to combat this worldwide health concern, Michael Niederweis, Ph.D., and colleagues from the University of Alabama at Birmingham have made an important discovery. The scientists recently uncovered an important toxin called Tuberculosis Necrotizing Toxin (TNT) that resides within the pathogenic bacterium Mycobacterium tuberculosis and aids in survival and proliferation.

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Tags: tuberculosis, Immunology, Alabama, Biology, 2015, disease research, life science research, UAlab, Birmingham, AL, Southern Region, University of Alabama at Birmingham, BioResearch Product Faire™

Irvine Bio Research Discovers Body Clock Key to Gut Immune Response

Posted by Jaimee Saliba on Fri, Jun 07, 2013

Your body's circadian clock is responsible for making sure you stay healthy, by regulating metabolism and carrying out internal housekeeping chores on a steady 24-hour schedule. About 15% of genes are controlled by your bodily clock, including some important ones in your intenstines that keep infectious bacteria like salmonella in check. Dr. Paolo Sassone-Corsi is a professor of biological chemistry at the UC Irvine School of Medicine and Director of UCI's Center for Epigenetics and Metabolism. Together with his colleague, microbiologist Manuela Raffatellu of UCI's Institute for Immunology, the Irvine bio research team has recently published an article in PNAS revealing how the immune system, specifically as it works in your intestinal track, is strongly directed by circadian rhythms. Upset that biological timing and you put yourself at greater risk of getting sick.

[Drs. Sassone-Corsi and RAffatellu, courtesy of Jocelyn Lee / University Communications at UCI]

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Tags: 2014, CA, 2013, University of California Irvine, Immunology, epigenetics, Southwest, California, University of California, Immune System, BioResearch Product Faire Event, Irvine, UCI, biological clock

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