Anyone who's ever pulled an all-nighter to finish a project knows how it wreaks havoc with your metabolism. The fact is, it's not just a nicety to be awake and active during the day and sleep at night: it's the way bodies are hard-wired. Scientists have long-suspected that upsets in a person's biological clock could play a factor in the development of metabolic disorders like diabetes. Now a team of researchers from three Southern California universities has made surprising discoveries that support that hypothesis. Not only have they isolated the protein that regulates the biologic clock (and named it cryptochrome), but they have found a molecule called KL001 that dictates when cryptochrome gets sent to the proteasome recycling bin. Which is to say, they now know a lot more about this complex circadian system that not only tells the body when to sleep and wake, but also how the body should manage glucose levels in those periods of relative activity and dormancy. The bio research study was published in the July 13 advance online issue of the journal Science.
Science Market Update
Tags: CA, University of California San Diego, University of Southern California, Diabetes, Southwest, California, 2012, University of California Santa Barbara, USC, Los Angeles, Biochemistry, Scripps, biology research, bio research, Front Line event, NSF
If you watch the evening news in Northern California, it's not unusual to hear the results of studies being done at Sacramento's UC Davis Medical Center campus, especially if those results are raising eyebrows. But an autism study out of the M.I.N.D. Institute at UCDMC has gone national recently, appearing on dozens of media outlets, as well as in Monday's issue of the journal Pediatrics. The news? Research study results showing a corellation between a mother's obesity during pregnancy and increased risk for autism in her child. More specifically, women with metabolic diseases like obesity, diabetes, and hypertension were 1.6 times more likely to have children with autism spectrum disorders than healthy women.
There is still no magic pill for the two-thirds of Americans who are overweight, but research into the cellular mechanism of fat production is turning up promising avenues for therapeutics that are closer than you might think. We mentioned "good brown fat" in a recent article on hormone research at Harvard. Scientists in the Diabetes Center and the Department of Cell and Tissue Biology at the University of California San Francisco, Parnassus Campus, are also looking at brown fat production as a treatment for obesity.
Thanks to a longtime Minnesota philanthropist and the State of Minnesota, neuroscience and diabetes researchers at the University of Minnesota and the Mayo Clinic are looking at millions in research grant funding from two new programs: