Researchers at the University of Alabama, Birmingham have discovered a potential new approach to reducing the damage done by Parkinson's disease. They found that suppressing a key cell-signaling pathway in the brain lessened the destructive inflammation and nerve degradation in the area of the brain affected by Parkinson’s. In the study, rats were used to model the disease by inducing an overexpression of a-synuclein, a protein that is abundant in the human brain. The accumulation of α-synuclein is a core feature of Parkinson’s disease. This accumulation leads to the activation of the brain's immune cells and the production of inflammatory signaling chemicals, which leads to neurodegradation. The rats that were then given a JAK/STAT pathway inhibitors (known as Jakinibs) did not have the immune response, the inflammatory activation, or the neurodegeneration that those that did not receive the inhibitor experienced.Read More
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With Zika outbreaks in Mexico, Central America, and South America, the National Institute of Child Health and Human Development (NICHD) is attempting to stop the virus at our border. To assist with this effort, the institute is funding a study led by Dr. William Britt, Professor of Pediatric Infectious Diseases at the University of Alabama at Birmingham (UAB). This study will take place in Brazil, where the World Health Organization (WHO) estimates that between 500,000 and 1.5 million people have been infected by Zika. The study will follow pregnant women in Brazil regardless of their Zika virus infection status and follow the infants suspected of having Zika from birth until 2 years of age.Read More
Tuberculosis is a terrible disease that is characterized by a bad, sometimes bloody cough, and which could lead to other serious health problems, or even death.
Over 1.5 million people currently die from TB each year, and as many as one third of the world’s population is currently infected, according to the Centers for Disease Control and Prevention.
In an effort to combat this worldwide health concern, Michael Niederweis, Ph.D., and colleagues from the University of Alabama at Birmingham have made an important discovery. The scientists recently uncovered an important toxin called Tuberculosis Necrotizing Toxin (TNT) that resides within the pathogenic bacterium Mycobacterium tuberculosis and aids in survival and proliferation.Read More
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Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. Nearly all cases of cervical cancer are believed to be caused by HPV infection, which cause more than 270,000 deaths annually. Of the more than 85% are in developing countries.
Researchers at the University of Alabama recently received $8.1 million in life science funding from the National Institutes of Health for a study involving the etiology of geographic and racial differences in stroke. The life science grant was awarded in January of 2014 by the National Institute of Neurological Disorders and Stroke, a branch within the National Institutes of Health.
The University of Alabama, Birmingham recently renewed its translational research facility, the Comprehensive Cancer Center/ Wallace Tumor Institute, which is home to a number of state-of-the art research laboratories for leading cancer diagnostic and treatment research in Alabama.
Living 17 years in a Dadaab refugee camp after fleeing Somalia, Africa, Hussein Issak Magale with his family came to the United States with a resettlement opportunity in 2009. After starting off at the University of Arizona in April 2010, Magale has worked in the Orthopaedic Research Lab and participated in an international research program in Kenya, Africa, which is funded by the National Institutes of Health and administrated by the University of Alabama. He will graduate in this May 2014 with a Bachelor of Science in Molecular and Cellular Biology.
The University of Alabama at Birmingham recently received a $4.6 million life science research funding grant from the NIH for the school’s Center for Clinical and Translational Science. Dr. Robert Kimberly is listed as the project leader. According to the University of Alabama, Dr. Kimberly is Senior Associate Dean for Research and Director of the University of Alabama at Birmingham Arthritis and Musculoskeletal Center (AMC). He is also a rheumatologist and immunologist whose research interests include autoimmune disease, systemic lupus erythematosus, systemic vasculitis and rheumatoid arthritis. The NIH RePORTER provides more information on the center receiving the latest $4.6 million in life science funding.
Reading our Science Market Update blog is a great way to stay informed of industry trends and research, funding and life science building news, but did you know that there is also a great deal of funding and life science market news available on our company news blog? We have put together a list, including links to the articles, of some recent news posted on our Life Science Company and Industry News Briefs blog available to life science sales and marketing professionals interested in staying informed of life science marketing and industry news.
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Iron is the most common chemical element found on earth, and it plays a key role in the biochemical processes of almost all organisms. Though iron is an important building block of life, it is also attributed to causing cellular damage when it is released into its free catalytic form. Researchers at the University of Alabama at Birmingham recently published a report in the Journal of Clinical Investigation which sought to help understand the relationship between the protein ferritin and kidney damage caused by this free iron. This study set a foundation for future research into potential treatments to prevent acute kidney injury.