Researchers at the University of California, Santa Barbara have discovered the age and origin of an E280A gene mutation that has caused early-onset Alzheimer’s in a Columbian family. The family, whose members have had Alzheimer’s with more frequency than most families, was traced to a single founder dating from the 1500’s. The research team sequenced the genomes of more than 100 family members and identified the regions of common ancestry. They then used this information to trace the source of the Alzheimer’s mutation.
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