Researchers at the Ohio State University Comprehensive Cancer Center have identified a gene mutation that they estimate dates back to 11,600 B.C. This ancient date of origin makes the mutation the second oldest human disease mutation ever discovered. The investigators believe that the mutation arose in the Middle East about 13,600 years ago, making it second in age only to a mutation in cystic fibrosis that arose between 11,000 and 52,000 years ago.
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