Science Market Update

Columbia Researchers Use Printer To Repair Knees

Posted by Laura Braden on Tue, Dec 23, 2014

Every year about 1 million surgeries in the United States are performed to repair torn meniscus, the protective cartilage in the knee. When this cartilage is damaged, it can cause pain and lead to serious arthritis. Current treatments to repair meniscus involve performing a transplant with tissue taken from either different areas in the body or from a cadaver,. This method, however, has significant risks and relatively low success rates. 

Researchers at Columbia University Medical Center in New York have been studying new methods for repairing this knee tissue, and have recently developed a way to use 3D-printed implants to replace torn or damaged meniscus

The meniscus is an ear-shaped tissue that protects the knee. When torn, it can lead to pain and arthritis.
Jeremy Mao, DDS, Ph.D., the Columbia leader of this study, explained that there is currently not a lot that doctors can do to repair torn meniscus. “Some small tears can be sewn back in place, but larger tears have to be surgically removed. While removal helps reduce pain and swelling, it leaves the knee without the natural shock absorber between the femur and tibia, which greatly increases the risk of arthritis,” Mao said. 
(Image on left showing different tears in meniscus, courtesy of Wikimedia Commons)

To find new methods of repairing meniscus, the Columbia research team used a 3D-printer to produce an implant of a meniscus infused with two human growth proteins. These proteins help the body regenerate knee tissue by attracting existing stem cells and using them to create new tissue. 

They then tested these newly printed meniscus in sheep because the knees of sheep are very similar to those of humans. Sheep were broken up into different groups, and some were given an implant with the human growth proteins and others were given the implant without the proteins. They found that after 3 months of receiving the implant, the sheep who had received an implant infused with the two human growth proteins were able to walk normally. Furthermore, the tissue that regenerated with the help of the implant and proteins had similar structural and mechanical properties to natural meniscus. 

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Dr. Mao explained that "this is a departure from classic tissue engineering, in which stems cells are harvested from the body, manipulated in the laboratory, and then returned to the patient—an approach that has met with limited success. In contrast, we’re jumpstarting the process within the body, using factors that promote endogenous stem cells for tissue regeneration.”

Further study needs to be undertaken to see if these regenerated tissues are long-lasting o short lived, but this current success in sheep leads to new possibilities in using 3D-printed implants in repairing torn tissues. 

Two National Institute of Health grants were used to help fund this project, one grant for $1.01 million, and a second for $547 thousand

Watch the video below to see the printing process of the new meniscus:

 

(Video courtesy of Youtube.com)


Columbia University Medical Center researchers receive millions of dollars annually to support their research projects, and to help begin new projects. Other current life science research projects receiving funding at Columbia University include: 

  • Researchers at Columbia University received a four year $12.6 million grant from the NIH to study rare genetic variants that can either protect against or contribute to the risk of Alzheimer's disease. 
  • Columbia University Medical Center's Michael Shen, PhD of the Departments of Medicine and Genetics & Development and the Herbert Irving Comprehensive Cancer Center received a five-year $6.9 million grant from the National Cancer Institute for a study titled “Molecular Mechanisms of Prostate Cancer Initiation.”
  • The National Institute of Allergy and Infectious Diseases awarded research lab scientists at Columbia University $6.3 million in research funding for Columbia’s Center for Research in Diagnostics and Discovery.

 

Annual Research Event At Columbia

The annual BioResearch Product Faire™ Event at Columbia University gives these well-funded New York area researchers the opportunity to find new lab supplies that will benefit their labs and research. Lab supply companies interested in marketing their products in the Columbia marketplace are encouraged to attend a BioResearch Product Faire™ Event in New York where they can meet face-to-face with researchers. 

Due to the popularity of the Columbia event in the past, Biotechnology Calendar, Inc. will be holding two events at Columbia University in 2015, one in the spring and one in the fall. To learn more about participating in these events, either as an exhibitor or researcher, visit the appropriate link below. 

 

Learn More About  Columbia Event          Researchers Attend Columbia Event

 

Other events in the New York region can be found by visiting the 2015 calendar of events for the Northeast region here.  

 

Tags: Northeast, 2015, Columbia, BioResearch Product Faire Event, NY, Columbia University Medical Center

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