Science Market Update

Cheating Amoeba Caught at Washington University

Posted by Sam Asher on Thu, Jan 24, 2013

In the game of life, cheating doesn’t pay off. Laws, karma, and conscience all work towards keeping things just and fair. However, in the world of bacteria, these rules don’t seem to apply. Researchers from the Washington University at St. Louis have reported a strain of amoeba that favors selfishness over fairness, and doesn’t seem to even pay a price for it.

The cheater amoeba is called Dictyostelium discoideum, and lives at ground level on the floors of North American forests. There, it lives a predatory lifestyle, hunting down bacteria and other cellular treats. When food runs scarce and bellies start to growl, the amoebae of the area call an emergency meeting and gather in one place. There they begin to clump together in what is known as a fruiting body, which resembles a tiny dandelion made out of amoebae. And very much like a dandelion, the top of the fruiting body produces “spores” that are sent out to find a place with, hopefully, a better chance of finding a meal.

amoeba bioresearch

(An example of fruiting bodies, with spores at the top. Courtesy National Geographic)

Since not all the amoeba that form the fruiting body become part of the spores, many of the participants die off in the process, especially those near the bottom of the stalk. Processes like these are known as cooperative, because the organisms work together so that the group as a whole has a better chance of survival. D. Discoideum takes advantage of the collaborative situation, and “cheats” by contributing more than its fair share of genes to the spores. This means that it dominates the next generation of amoeba even if it wasn’t the most abundant amoeba in the fruiting body.

fruiting body formsNow, cheaters such as this do exist in the microscopic world, but they usually pay a price for it. For example, a relative of D. Discoideum (aptly named CheaterA) pulls a very similar stunt, but cannot produce fruiting bodies on its own. So, when CheaterA takes over amoeba populations by crowding the gene pool, it finds that it can no longer produce the fruiting bodies it used to take advantage of. (Some other forms of fruiting bodies appear left, courtesy of Wikimedia Commons.) By contrast, D. Discoideum appears to suffer no disadvantages from its trickery, as professors David Queller and Joan Strassman of Washington University assert in this WUSTL article. This could have paradigm-shifting implications about the role of cheating in nature and whether it’s something researchers could experiment with in the lab. Strassman, however, is loathe to throw morals out the window just yet:

“No measurable laboratory trait revealed an Achilles heel, but that doesn’t mean there isn’t one in natural environments. Otherwise, why would a naturally occurring mutation that duplicated the knockout not take over amoebae populations?”



 Strassman makes a compelling point that further research can hopefully address. To read more about Washington University at St. Louis research and funding information, feel free to peruse our WUSTL Funding Statistics Report:

 Washington Funding Statistics

Biotechnology Calendar, Inc. will be on the Washington University campus next on May 23rd, 2013 for our St. Louis BioResearch Product Faire™ event. This show is an excellent opportunity for life science scientists and laboratory equipment suppliers to network and discuss their research needs and solutions. To see our 2013 show scheduleclick here. To attend the St. Louis BioResearch Product Faire™ specifically, click this button:

 Exhibit At St Louis

Tags: 2014, Midwest, 2013, Washington University, WashU, BioResearch Product Faire Event, MO, St Louis, laboratory equipment, Dictyostelium discoideum

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