Science Researcher Update: Spotlight on Meetings, Conferences, and Events

7th Annual Swiss Zebrafish Meeting

Posted on Feb 21, 2014 12:49:00 PM

The 7th Swiss Zebrafish Meeting

Meeting - Geneva, Switzerland

A Ph.D student position is immediately available in the laboratory of Prof. Marguerite Neerman-Arbez, Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Switzerland.

We are studying human genetic disorders of hemostasis, in particular fibrinogen deficiencies. These are rare and affect either the quantity or the quality of circulating fibrinogen, which is the precursor of the major protein component of the blood clot, fibrin. Our laboratory identified the gene and the first causative mutations for complete deficiency of fibrinogen, afibrinogenemia, in 1999. Fibrinogen is a hexamer comprising two copies of three polypeptides. These are encoded by the fibrinogen alpha, beta and gamma genes clustered on human chromosome 4. While still pursuing studies of the molecular mechanisms by which fibrinogen gene mutations lead to disease, we are investigating the broader picture influencing fibrinogen levels (which are highly variable amongst individuals) identifying new regulatory elements in the genomic landscape of the fibrinogen cluster. We are also determining how microRNAs are involved in the fine-tuning of fibrinogen levels. Animal models i.e. the zebrafish (Danio rerio) are used in the course of these projects


(Courtesy of University of Geneva, Geneva, Switzerland, via

for representative publications see

April 24-25, 2014 

University of Geneva, Geneva, Switzerland

Tags: 2014, April, Medicine, Research Meeting, Switzerland, Geneva, genomic, Life Sciences, Genetics

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