Meeting - Geneva, Switzerland
Confirmed Keynote speakers:
Derek Stemple, The Wellcome Trust Sanger Institute, Hinxton, UK.
Roger Patient, The MRC Weatherall Institute of Molecular Medicine,Univeristy of Oxford, UK.
Professor Patient will give the EMBO lecture Molecular Genetics of Haemostasis
OpportunitieS Ph.D. student position
A Ph.D student position is immediately available in the laboratory of Prof. Marguerite Neerman-Arbez, Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Switzerland. http://www.unige.ch/medecine/phdprogram/groups/neerman-arbez.html.
We are studying human genetic disorders of hemostasis, in particular fibrinogen deficiencies. These are rare and affect either the quantity or the quality of circulating fibrinogen, which is the precursor of the major protein component of the blood clot, fibrin. Our laboratory identified the gene and the first causative mutations for complete deficiency of fibrinogen, afibrinogenemia, in 1999. Fibrinogen is a hexamer comprising two copies of three polypeptides. These are encoded by the fibrinogen alpha, beta and gamma genes clustered on human chromosome 4. While still pursuing studies of the molecular mechanisms by which fibrinogen gene mutations lead to disease, we are investigating the broader picture influencing fibrinogen levels (which are highly variable amongst individuals) identifying new regulatory elements in the genomic landscape of the fibrinogen cluster. We are also determining how microRNAs are involved in the fine-tuning of fibrinogen levels. Animal models i.e. the zebrafish (Danio rerio) are used in the course of these projects
(Courtesy of University of Geneva, Geneva, Switzerland, via flickr.com)
for representative publications see http://www.unige.ch/medecine/swisszebra2014/home.html
April 24-25, 2014
University of Geneva, Geneva, Switzerland
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