Workshop - Stockholm, Sweden
Considering the key role of mitochondria in energy metabolism and in regulation of cell death, it appears that resistance of most tumors towards treatment can be, at least in part, explained by mitochondrial silencing in cancer cells. The goal of the EMBO Workshop is to bring together world leaders in several areas of biology and medicine, focusing on mitochondria that recently became an intriguing target for cancer therapy.
Heterogeneity of tumors dictates an individual approach to anticancer treatment. Despite their variability, almost all cancer cells demonstrate enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect, whereas mitochondrial activity in tumor cells is suppressed. Alterations in mitochondrial functions account for multiple aspects of metabolic reprogramming of transformed cells. Differences in mitochondrial functions between tumor and normal cells can be utilized to design selective anti-cancer therapies. Thus, a better understanding of cancer-specific alterations in mitochondrial physiology will open new perspectives to specifically target mitochondria of malignant cells. The inefficacy of established cancer therapies is to a large extent the result of oncogenic blockade of cell death pathways, therefore, compounds that directly affect mitochondrial functions are considered to present a promising alternative approach to eradicate chemotherapy-resistant cancers.
(Courtesy of Karolinska Institutet, Stockholm, Sweden, via mark.space.4goo.net)
Thu, Oct 10, 2013 - Sat, Oct 12, 2013
Nobels väg. 1, Karolinska Institutet, Stockholm, Sweden
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